Universität zu Köln

Wieland, Ulrike, Silling, Steffi, Hellmich, Martin, Potthoff, Anja, Pfister, Herbert and Kreuter, Alexander (2014). Human polyomaviruses 6, 7, 9, 10 and Trichodysplasia spinulosa-associated polyomavirus in HIV-infected men. J. Gen. Virol., 95. S. 928 - 933. READING: SOC GENERAL MICROBIOLOGY. ISSN 1465-2099

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Abstract

Recently, several novel human polyomaviruses (HPyVs) have been detected. HPyV6, 7, 9 and 10 are not associated with any disease so far. Trichodysplasia spinulosa (TS)-associated polyomavirus (TSPyV) can cause the rare skin disease TS. We have evaluated cutaneous DNA prevalence and viral loads of five HPyVs in HIV-infected men compared to healthy male controls. 449 forehead swabs were analysed by HPyV-specific real-time PCR. HPyV6, HPyV7, TSPyV and HPyV10 were found significantly more frequently on the skin of 210 HIV-infected compared to 239 HIV-negative men (HPyV6, 39.0 vs 27.6%; HPyV7, 21.0 vs 13.4%; TSPyV, 3.8 vs 0.8 %; HPyV10, 9.3 vs 3.4%; P<0.05, respectively). HPyV9 was not detected. Multiple infections were more frequent in HIV-positive men, but HPyV-DNA loads did not differ significantly in both groups. In contrast to HPyV6, 7 and 10, TSPyV and HPyV9 do not seem to be a regular part of the human skin nnicrobiome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wieland, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Silling, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Potthoff, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-440974
DOI:	10.1099/vir.0.061259-0
Journal or Publication Title:	J. Gen. Virol.
Volume:	95
Page Range:	S. 928 - 933
Date:	2014
Publisher:	SOC GENERAL MICROBIOLOGY
Place of Publication:	READING
ISSN:	1465-2099
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MERKEL CELL POLYOMAVIRUS; LYMPHOTROPIC POLYOMAVIRUS; CROSS-REACTIVITY; SEROPREVALENCE; CARCINOMA Multiple languages Biotechnology & Applied Microbiology; Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44097