Universität zu Köln

Rabenhorst, Anja and Hartmann, Karin ORCID: 0000-0002-4595-8226 (2014). Interleukin-31: A Novel Diagnostic Marker of Allergic Diseases. Curr. Allergy Asthma Rep., 14 (4). PHILADELPHIA: CURRENT MEDICINE GROUP. ISSN 1534-6315

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Abstract

Interleukin-31 (IL-31) is a newly discovered cytokine associated with chronic skin inflammation and pruritus. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin. Interestingly, in some of these diseases, IL-31 serum levels correlate with disease activity. In the present review, we particularly focus on studies investigating IL-31 as a novel diagnostic biomarker indicating the severity of allergic diseases. We highlight a recent study on IL-31 in mastocytosis, which reports on elevated serum levels of IL-31 in adults correlating with the severity of disease categories, tryptase levels and percentage of bone marrow infiltration. We conclude that growing knowledge about IL-31, its receptors and signaling pathways serves to better understand the pathogenesis of allergic diseases and may lead to the development of novel treatment approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rabenhorst, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Karin UNSPECIFIED orcid.org/0000-0002-4595-8226 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-441521
DOI:	10.1007/s11882-014-0423-y
Journal or Publication Title:	Curr. Allergy Asthma Rep.
Volume:	14
Number:	4
Date:	2014
Publisher:	CURRENT MEDICINE GROUP
Place of Publication:	PHILADELPHIA
ISSN:	1534-6315
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language T-CELLS; SCRATCHING BEHAVIOR; IL-31 POLYMORPHISMS; GENE-EXPRESSION; NC/NGA MICE; SERUM IL-31; CYTOKINE; DERMATITIS; SEVERITY; PRURITUS Multiple languages Allergy; Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44152