Universität zu Köln

Harrison, Fiona E., Bowman, Gene L. and Polidori, Maria Cristina (2014). Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline. Nutrients, 6 (4). S. 1752 - 1782. BASEL: MDPI. ISSN 2072-6643

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Abstract

This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive decline up to Alzheimer's disease. Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Harrison, Fiona E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bowman, Gene L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442806
DOI:	10.3390/nu6041752
Journal or Publication Title:	Nutrients
Volume:	6
Number:	4
Page Range:	S. 1752 - 1782
Date:	2014
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6643
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VITAMIN-C TRANSPORTERS; INCREASED OXIDATIVE STRESS; ALZHEIMERS-DISEASE; LIPID-PEROXIDATION; SUPPLEMENT USE; RISK-FACTORS; CELL-DEATH; REGIONAL-DISTRIBUTION; ANTIOXIDANT STATUS; DNA DEMETHYLATION Multiple languages Nutrition & Dietetics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44280