Universität zu Köln

Kornfeld, Jan-Wilhelm ORCID: 0000-0002-6802-4442 and Bruening, Jens C. (2014). Regulation of metabolism by long, non-coding RNAs. Front. Genet., 5. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-8021

Full text not available from this repository.

Abstract

Our understanding of genomic regulation was revolutionized by the discovery that the genome is pervasively transcribed, giving rise to thousands of mostly uncharacterized non-coding ribonucleic acids (ncRNAs). Long, ncRNAs (IncRNAs) have thus emerged as a novel class of functional RNAs that impinge on gene regulation by a broad spectrum of mechanisms such as the recruitment of epigenetic modifier proteins, control of mRNA decay and DNA sequestration of transcription factors. We review those IncRNAs that are implicated in differentiation and homeostasis of metabolic tissues and present novel concepts on how IncRNAs might act on energy and glucose homeostasis. Finally, the control of circadian rhythm by IncRNAs is an emerging principles of IncRNA-mediated gene regulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kornfeld, Jan-Wilhelm UNSPECIFIED orcid.org/0000-0002-6802-4442 UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-443172
DOI:	10.3389/fgene.2014.00057
Journal or Publication Title:	Front. Genet.
Volume:	5
Date:	2014
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-8021
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMPAIRS GLUCOSE-METABOLISM; BETA-CELL TRANSCRIPTOME; BROWN ADIPOSE-TISSUE; GENE-EXPRESSION; IN-VIVO; LIPID-METABOLISM; MESSENGER-RNAS; INSULIN-RESISTANCE; CHROMATIN; GENOME Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44317