Universität zu Köln

Escobar-Henriques, Mafalda ORCID: 0000-0002-0879-3119 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2014). Dynamic survey of mitochondria by ubiquitin. EMBO Rep., 15 (3). S. 231 - 244. HOBOKEN: WILEY. ISSN 1469-3178

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Abstract

Abstract Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes. At mitochondria, it performs regulatory homeostatic functions and contributes to mitochondrial quality control. Ubiquitin is essential for mitochondrial fusion, regulates mitochondria-ER contacts, and participates in maternal mtDNA inheritance. Under stress, mitochondrial dysfunction induces ubiquitin-dependent responses that involve mitochondrial proteome remodeling and culminate in organelle removal by mitophagy. In addition, many ubiquitin-dependent mechanisms have been shown to regulate innate immune responses and xenophagy. Here, we review the emerging roles of ubiquitin at mitochondria.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Escobar-Henriques, Mafalda UNSPECIFIED orcid.org/0000-0002-0879-3119 UNSPECIFIED Langer, Thomas UNSPECIFIED orcid.org/0000-0003-1250-1462 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-444517
DOI:	10.1002/embr.201338225
Journal or Publication Title:	EMBO Rep.
Volume:	15
Number:	3
Page Range:	S. 231 - 244
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1469-3178
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOPLASMIC-RETICULUM; MITOFUSIN 2; E3 LIGASE; PATERNAL MITOCHONDRIA; MATERNAL INHERITANCE; PROTEASOME SYSTEM; AXONAL-TRANSPORT; PINK1 FUNCTION; GENOME-WIDE; PARKIN Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/44451