Brinkmann, K. and Kashkar, H. (2014). Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies? Cell Death Dis., 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-4889
Full text not available from this repository.Abstract
Acquired resistance toward apoptosis represents one of the hallmarks of human cancer and a major cause of the inefficacy of most anticancer treatment regimens. Based on its ability to inhibit apoptosis, the B-cell lymphoma/leukemia 2 (Bcl-2) protein family has garnered the most attention as a promising therapeutic target in cancer. Accordingly, efforts have lately been focused on the development of drugs targeting Bcl-2 proteins with considerable therapeutic success, particularly in hematologic malignancies. Here, we review the previous studies and highlight the pivotal role of the Bcl-2 protein family in the homeostasis of hematologic tissue compartment. This knowledge provides more insight into why some cancers are more sensitive to Bcl-2 targeting than others and will foster the clinical evaluation of Bcl-2-targeting strategies in cancer by avoiding severe on-target side effects in the development of healthy tissues.
| Item Type: | Journal Article | ||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-445198 | ||||||||||||
| DOI: | 10.1038/cddis.2014.61 | ||||||||||||
| Journal or Publication Title: | Cell Death Dis. | ||||||||||||
| Volume: | 5 | ||||||||||||
| Date: | 2014 | ||||||||||||
| Publisher: | NATURE PUBLISHING GROUP | ||||||||||||
| Place of Publication: | LONDON | ||||||||||||
| ISSN: | 2041-4889 | ||||||||||||
| Language: | English | ||||||||||||
| Faculty: | Unspecified | ||||||||||||
| Divisions: | Unspecified | ||||||||||||
| Subjects: | no entry | ||||||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/44519 |
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