Universität zu Köln

Willenborg, Sebastian and Eming, Sabine A. (2014). Macrophages - sensors and effectors coordinating skin damage and repair. J. Dtsch. Dermatol. Ges., 12 (3). S. 214 - 224. HOBOKEN: WILEY. ISSN 1610-0387

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Abstract

Restoration of skin integrity and homeostasis following injury is a vital process. Wound healing disorders, including chronic skin ulcers and pathological scarring, are of major clinical impact. The current therapeutic approaches are often not sufficient. The development of novel efficient therapies requires a thorough understanding of the underlying molecular mechanisms. A cardinal feature of non-healing skin ulcers and excessive scarring is a prolonged inflammatory response at the wound site, which aborts the healing response. Modulation of the local immune response may be an effective therapeutic strategy to correct impaired healing conditions. Yet, the specific mechanisms of inflammation, particularly the role of the diverse leukocyte lineages attracted to the site of tissue damage, have not been resolved. Recent findings in diverse experimental model systems and clinical studies have refined the understanding of monocyte/macrophage biology and the role of cells of the monocytic lineage in tissue regeneration. Thus, monocytes/macrophages are emerging as novel and interesting therapeutic targets to interfere in wound healing pathologies. In this article we will review the role of monocytes/macrophages in skin repair in the light of the recent literature and findings from our own group. This article will provide a rationale for monocyte/macrophage-based therapies to facilitate the healing response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Willenborg, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-445346
DOI:	10.1111/ddg.12290
Journal or Publication Title:	J. Dtsch. Dermatol. Ges.
Volume:	12
Number:	3
Page Range:	S. 214 - 224
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1610-0387
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REMITTING MULTIPLE-SCLEROSIS; TISSUE-REPAIR; IN-VIVO; ALTERNATIVE ACTIVATION; INFLAMMATORY MONOCYTES; CONTROLLED-TRIAL; PROTECTS MICE; WOUND REPAIR; REGENERATION; BLOOD Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44534