Universität zu Köln

Behrens, Axel ORCID: 0000-0002-1557-1143, van Deursen, Jan M., Rudolph, K. Lenhard and Schumacher, Bjoern (2014). Impact of genomic damage and ageing on stem cell function. Nat. Cell Biol., 16 (3). S. 201 - 208. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4679

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Abstract

Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behrens, Axel UNSPECIFIED orcid.org/0000-0002-1557-1143 UNSPECIFIED van Deursen, Jan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, K. Lenhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-445492
DOI:	10.1038/ncb2928
Journal or Publication Title:	Nat. Cell Biol.
Volume:	16
Number:	3
Page Range:	S. 201 - 208
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-4679
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DNA-DAMAGE; SELF-RENEWAL; TELOMERE DYSFUNCTION; OXIDATIVE STRESS; MICE LEADS; LIFE-SPAN; ATM; CANCER; GROWTH; SENESCENCE Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44549