Universität zu Köln

Sayou, Camille ORCID: 0000-0002-8226-7272, Monniaux, Marie ORCID: 0000-0001-6847-3902, Nanao, Max H., Moyroud, Edwige ORCID: 0000-0001-7908-3205, Brockington, Samuel F., Thevenon, Emmanuel, Chahtane, Hicham ORCID: 0000-0002-0976-1186, Warthmann, Norman ORCID: 0000-0002-1178-8409, Melkonian, Michael, Zhang, Yong, Wong, Gane Ka-Shu, Weigel, Detlef ORCID: 0000-0002-2114-7963, Parcy, Francois ORCID: 0000-0003-2191-500X and Dumas, Renaud (2014). A Promiscuous Intermediate Underlies the Evolution of LEAFY DNA Binding Specificity. Science, 343 (6171). S. 645 - 649. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

Transcription factors (TFs) are key players in evolution. Changes affecting their function can yield novel life forms but may also have deleterious effects. Consequently, gene duplication events that release one gene copy from selective pressure are thought to be the common mechanism by which TFs acquire new activities. Here, we show that LEAFY, a major regulator of flower development and cell division in land plants, underwent changes to its DNA binding specificity, even though plant genomes generally contain a single copy of the LEAFY gene. We examined how these changes occurred at the structural level and identify an intermediate LEAFY form in hornworts that appears to adopt all different specificities. This promiscuous intermediate could have smoothed the evolutionary transitions, thereby allowing LEAFY to evolve new binding specificities while remaining a single-copy gene.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sayou, Camille UNSPECIFIED orcid.org/0000-0002-8226-7272 UNSPECIFIED Monniaux, Marie UNSPECIFIED orcid.org/0000-0001-6847-3902 UNSPECIFIED Nanao, Max H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moyroud, Edwige UNSPECIFIED orcid.org/0000-0001-7908-3205 UNSPECIFIED Brockington, Samuel F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevenon, Emmanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Chahtane, Hicham UNSPECIFIED orcid.org/0000-0002-0976-1186 UNSPECIFIED Warthmann, Norman UNSPECIFIED orcid.org/0000-0002-1178-8409 UNSPECIFIED Melkonian, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Yong UNSPECIFIED UNSPECIFIED UNSPECIFIED Wong, Gane Ka-Shu UNSPECIFIED UNSPECIFIED UNSPECIFIED Weigel, Detlef UNSPECIFIED orcid.org/0000-0002-2114-7963 UNSPECIFIED Parcy, Francois UNSPECIFIED orcid.org/0000-0003-2191-500X UNSPECIFIED Dumas, Renaud UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-446000
DOI:	10.1126/science.1248229
Journal or Publication Title:	Science
Volume:	343
Number:	6171
Page Range:	S. 645 - 649
Date:	2014
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	1095-9203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REGULATOR; DIVERSITY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44600