Universität zu Köln

Gassanov, Natig, Nia, Amir M., Caglayan, Evren and Er, Fikret (2014). Remote Ischemic Preconditioning and Renoprotection: From Myth to a Novel Therapeutic Option? J. Am. Soc. Nephrol., 25 (2). S. 216 - 225. WASHINGTON: AMER SOC NEPHROLOGY. ISSN 1533-3450

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Abstract

There is currently no effective prophylactic regimen available to prevent contrast-induced AKI (CI-AKI), a frequent and life-threatening complication after cardiac catheterization. Therefore, novel treatment strategies are required to decrease CI-AKI incidence and to improve clinical outcomes in these patients. Remote ischemic preconditioning (rIPC), defined as transient brief episodes of ischemia at a remote site before a subsequent prolonged ischemia/reperfusion injury of the target organ, is an adaptational response that protects against ischemic and reperfusion insult. Indeed, several studies demonstrated the tissue-protective effects of rIPC in various target organs, including the kidneys. In this regard, rIPC may offer a novel noninvasive and virtually cost-free treatment strategy for decreasing CI-AKI incidence. This review evaluates the current experimental and clinical evidence for rIPC as a potential renoprotective strategy, and discusses the underlying mechanisms and key areas for future research.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gassanov, Natig UNSPECIFIED UNSPECIFIED UNSPECIFIED Nia, Amir M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caglayan, Evren UNSPECIFIED UNSPECIFIED UNSPECIFIED Er, Fikret UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447692
DOI:	10.1681/ASN.2013070708
Journal or Publication Title:	J. Am. Soc. Nephrol.
Volume:	25
Number:	2
Page Range:	S. 216 - 225
Date:	2014
Publisher:	AMER SOC NEPHROLOGY
Place of Publication:	WASHINGTON
ISSN:	1533-3450
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONTRAST-INDUCED NEPHROPATHY; ACUTE-RENAL-FAILURE; ACUTE KIDNEY INJURY; REPERFUSION INJURY; NITRIC-OXIDE; CORONARY INTERVENTION; LIVER ISCHEMIA; LIMB ISCHEMIA; FREE-RADICALS; RISK-FACTORS Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44769