Universität zu Köln

Stein, Harald and Diehl, Volker (2014). First Hodgkin Cell Line L428 and the CD30 Antigen Their Role for Diagnostic and Treatment of CD30-positive Neoplasms. Hematol. Oncol. Clin. North Am., 28 (1). S. 1 - 13. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. ISSN 1558-1977

Full text not available from this repository.

Abstract

Hodgkin's disease (HD) is a fatal disorder with the unique histologic features of few dysplastic Hodgkin- and Reed-Sternberg (HRS) cells surrounded by an abundance of nonatypical bystander cells in primary biopsies. By using the first Hodgkin cell line L428 the cytokine receptor CD30 was discovered. CD30 proved to be an excellent target for the diagnoses of CD30+ malignancies and for monoclonal antibody therapy in patients with these malignancies because of its highly restricted expression in healthy individuals. Recently, a new anti-CD30-toxin-drug-conjugate consisting of an anti-CD30 monoclonal antibody bound to the nonimmunogenic toxin auristatin E with a newly designed linker was generated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stein, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447964
DOI:	10.1016/j.hoc.2013.10.007
Journal or Publication Title:	Hematol. Oncol. Clin. North Am.
Volume:	28
Number:	1
Page Range:	S. 1 - 13
Date:	2014
Publisher:	W B SAUNDERS CO-ELSEVIER INC
Place of Publication:	PHILADELPHIA
ISSN:	1558-1977
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REED-STERNBERG CELLS; IMMUNOGLOBULIN GENE REARRANGEMENTS; KI-1 ANTIGEN; IN-VIVO; B-CELL; DISEASE; EXPRESSION; LYMPHOMA; CULTURE; TISSUE Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44796