Schenten, Dominik, Nish, Simone A., Yu, Shuang, Yan, Xiting, Lee, Heung Kyu ORCID: 0000-0002-3977-1510, Brodsky, Igor, Pasman, Lesley, Yordy, Brian, Wunderlich, F. Thomas, Bruening, Jens C., Zhao, Hongyu and Medzhitov, Ruslan (2014). Signaling through the Adaptor Molecule MyD88 in CD4(+) T Cells Is Required to Overcome Suppression by Regulatory T Cells. Immunity, 40 (1). S. 78 - 91. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

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Abstract

Innate immune recognition controls adaptive immune responses through multiple mechanisms. The MyD88 signaling adaptor operates in many cell types downstream of Toll-like receptors (TLRs) and interleukin-1 (IL-1) receptor family members. Cell-type-specific functions of MyD88 signaling remain poorly characterized. Here, we have shown that the T cell-specific ablation of MyD88 in mice impairs not only T helper 17 (Th17) cell responses, but also Th1 cell responses. MyD88 relayed signals of TLR-induced IL-1, which became dispensable for Th1 cell responses in the absence of T regulatory (Treg) cells. Treg cell-specific ablation of MyD88 had no effect, suggesting that IL-1 acts on naive CD4(+) T cells instead of Treg cells themselves. Together, these findings demonstrate that IL-1 renders naive CD4(+) T cells refractory to Treg cell-mediated suppression in order to allow their differentiation into Th1 cells. In addition, IL-1 was also important for the generation of functional CD4(+) memory T cells.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schenten, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nish, Simone A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yu, ShuangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yan, XitingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Heung KyuUNSPECIFIEDorcid.org/0000-0002-3977-1510UNSPECIFIED
Brodsky, IgorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pasman, LesleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yordy, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wunderlich, F. ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruening, Jens C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, HongyuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medzhitov, RuslanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-448446
DOI: 10.1016/j.immuni.2013.10.023
Journal or Publication Title: Immunity
Volume: 40
Number: 1
Page Range: S. 78 - 91
Date: 2014
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4180
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INNATE IMMUNE-SYSTEM; TOLL-LIKE RECEPTORS; MEDIATED SUPPRESSION; RESPONSE LATE; CUTTING EDGE; BURN INJURY; IL-1; EXPRESSION; EXPANSION; DIFFERENTIATIONMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44844

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