Schenten, Dominik, Nish, Simone A., Yu, Shuang, Yan, Xiting, Lee, Heung Kyu ORCID: 0000-0002-3977-1510, Brodsky, Igor, Pasman, Lesley, Yordy, Brian, Wunderlich, F. Thomas, Bruening, Jens C., Zhao, Hongyu and Medzhitov, Ruslan (2014). Signaling through the Adaptor Molecule MyD88 in CD4(+) T Cells Is Required to Overcome Suppression by Regulatory T Cells. Immunity, 40 (1). S. 78 - 91. CAMBRIDGE: CELL PRESS. ISSN 1097-4180
Full text not available from this repository.Abstract
Innate immune recognition controls adaptive immune responses through multiple mechanisms. The MyD88 signaling adaptor operates in many cell types downstream of Toll-like receptors (TLRs) and interleukin-1 (IL-1) receptor family members. Cell-type-specific functions of MyD88 signaling remain poorly characterized. Here, we have shown that the T cell-specific ablation of MyD88 in mice impairs not only T helper 17 (Th17) cell responses, but also Th1 cell responses. MyD88 relayed signals of TLR-induced IL-1, which became dispensable for Th1 cell responses in the absence of T regulatory (Treg) cells. Treg cell-specific ablation of MyD88 had no effect, suggesting that IL-1 acts on naive CD4(+) T cells instead of Treg cells themselves. Together, these findings demonstrate that IL-1 renders naive CD4(+) T cells refractory to Treg cell-mediated suppression in order to allow their differentiation into Th1 cells. In addition, IL-1 was also important for the generation of functional CD4(+) memory T cells.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-448446 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1016/j.immuni.2013.10.023 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Immunity | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Volume: | 40 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Number: | 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 78 - 91 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | CELL PRESS | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Place of Publication: | CAMBRIDGE | ||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1097-4180 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/44844 |
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