Universität zu Köln

Schlereth, Simona L., Refaian, Nasrin ORCID: 0000-0001-8345-5972, Iden, Sandra ORCID: 0000-0003-2333-9827, Cursiefen, Claus and Heindl, Ludwig M. (2014). Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis. Biomed Res. Int., 2014. LONDON: HINDAWI LTD. ISSN 2314-6141

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Abstract

Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellular matrix as well as cytokines and growth factors are involved in the process of lymphangiogenesis and metastasis. The cellular and noncellular components influence each other and can be influenced by the tumor cells. The knowledge about mechanisms behind lymphangiogenesis in the tumor microenvironmental crosstalk is growing and offers starting points for new therapeutic approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schlereth, Simona L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Refaian, Nasrin UNSPECIFIED orcid.org/0000-0001-8345-5972 UNSPECIFIED Iden, Sandra UNSPECIFIED orcid.org/0000-0003-2333-9827 UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-449357
DOI:	10.1155/2014/639058
Journal or Publication Title:	Biomed Res. Int.
Volume:	2014
Date:	2014
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2314-6141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; FACTOR-C EXPRESSION; CHEMOKINE RECEPTOR CCR7; CILIARY-BODY-MELANOMAS; REGULATORY T-CELLS; NODE METASTASIS; DENDRITIC CELLS; BREAST-CANCER; COLORECTAL-CANCER Multiple languages Biotechnology & Applied Microbiology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44935