Neumann-Fraune, Maria, Beggel, Bastian, Kaiser, Rolf and Obermeier, Martin (2014). Hepatitis B Virus Drug Resistance Tools: One Sequence, Two Predictions. Intervirology, 57 (3-4). S. 232 - 237. BASEL: KARGER. ISSN 1423-0100
Full text not available from this repository.Abstract
Drug resistance testing, genotype analysis, and the determination of immune and vaccine escape variants support personalized antiviral treatment for hepatitis B patients. As phenotypic drug resistance testing for hepatitis B virus (HBV) is especially labor-intensive, due to the lack of simple cell culture systems, genotypic methods play a very pronounced role. The genetic structure of HBV allows the simultaneous analysis of two different genes by examination of a single region in the genome of HBV. Nevertheless, the overlapping open reading frames of the hepatitis B surface antigen (HBsAg) and the reverse transcriptase (RT) have to be interpreted separately. In diagnostic procedures, standard Sanger type sequencing (mostly performed as a dye-dideoxynucleotide terminator system) is still the most commonly used method. This allows using established techniques for interpreting those types of genetic information. Besides reviewing the foundation of drug resistance interpretation for HBV, different interpretation systems, either commercially available (TRUGENE, Abbott, ViroScore) or free to use (geno2pheno[HBV], HIV-GRADE HBV tool), are compared in this article. (C) 2014 S. Karger AG, Basel
| Item Type: | Journal Article | ||||||||||||||||||||
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| URN: | urn:nbn:de:hbz:38-449960 | ||||||||||||||||||||
| DOI: | 10.1159/000361076 | ||||||||||||||||||||
| Journal or Publication Title: | Intervirology | ||||||||||||||||||||
| Volume: | 57 | ||||||||||||||||||||
| Number: | 3-4 | ||||||||||||||||||||
| Page Range: | S. 232 - 237 | ||||||||||||||||||||
| Date: | 2014 | ||||||||||||||||||||
| Publisher: | KARGER | ||||||||||||||||||||
| Place of Publication: | BASEL | ||||||||||||||||||||
| ISSN: | 1423-0100 | ||||||||||||||||||||
| Language: | English | ||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/44996 |
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