Universität zu Köln

Ranjbar, Mahdy, Alt, Aizhan, Nassar, Khaled, Reinsberg, Mihaela, Schneider, Toni, Grisanti, Salvatore, Lueke, Julia and Lueke, Matthias (2014). The Concentration-Dependent Effects of Indocyanine Green on Retinal Function in the Electrophysiological ex vivo Model of Isolated Perfused Vertebrate Retina. Ophthalmic Res., 51 (3). S. 167 - 172. BASEL: KARGER. ISSN 1423-0259

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Abstract

Background: Dye solutions such as indocyanine green (ICG) are used for the staining of intraocular structures. The aim of the presented study was to investigate the effects of ICG on bovine retinal function using different concentrations of ICG. Methods: Bovine retina preparations were perfused with a standard solution and the electroretinogram was recorded. The nutrient solution was substituted by an ICG solution at varying concentrations for 45 min. Afterwards the preparations were reperfused with standard solution for at least 85 min. Results: Significant reductions in b-wave amplitude were found for concentrations of 0.0025% (p = 0.0099) and 0.025% (p = 0.0378). For the concentration of 0.025%, the b-wave amplitude remained significantly decreased (p = 0.0082) after the observation period, but a full recovery of the b-wave was observed for the concentration of 0.0025% (p = 0.1917). Conclusion: Intraocular application of sufficient ICG concentrations for internal limiting membrane staining seems not possible without interfering with retinal function. (C) 2014 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ranjbar, Mahdy UNSPECIFIED UNSPECIFIED UNSPECIFIED Alt, Aizhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Nassar, Khaled UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinsberg, Mihaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Toni UNSPECIFIED UNSPECIFIED UNSPECIFIED Grisanti, Salvatore UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueke, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueke, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450572
DOI:	10.1159/000357284
Journal or Publication Title:	Ophthalmic Res.
Volume:	51
Number:	3
Page Range:	S. 167 - 172
Date:	2014
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0259
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERNAL LIMITING MEMBRANE; MACULAR HOLE SURGERY; PIGMENT EPITHELIAL-CELLS; VITRECTOMY; EYES; BLUE; TOOL Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45057