Universität zu Köln

Rosentreter, Andre, Gaki, Stergiani, Cursiefen, Claus and Dietlein, Thomas S. (2014). Trabeculectomy Using Mitomycin C versus an Atelocollagen Implant: Clinical Results of a Randomized Trial and Histopathologic Findings. Ophthalmologica, 231 (3). S. 133 - 141. BASEL: KARGER. ISSN 1423-0267

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Abstract

Purpose: To assess the efficacy of trabeculectomy with a biodegradable Ologen (TM) implant (OLO) versus mitomycin C (MMC) in patients in a prospective randomized clinical trial. Methods: In the MMC group (15 patients), trabeculectomy was performed according to standard protocols. In the OLO group (15 patients) after standard trabeculectomy, the implant was positioned on top of the scleral flap, and no MMC was applied. Results: Mean preoperative intraocular pressure (IOP) levels (OLO: 28.0 +/- 9.4; MMC: 23.9 +/- 5.0 mm Hg; p = 0.21) and medication score (OLO: 3.4 +/- 1.6; MMC: 3.6 +/- 1.5; p = 0.56) were comparable in both groups. One year after surgery, the mean IOP was 15.9 +/- 4.5 mm Hg in the OLO group (p < 0.01, 43% reduction) and 11.0 +/- 2.6 mm Hg in the MMC group (p < 0.01, 54% reduction). The surgical success rate 12 months after surgery was 93.3% in the MMC group and 40% in the OLO group (p = 0.01). Conclusions: With the atelocollagen-glycosaminoglycan matrix OLO it was not possible to reach the surgical success rate and pressure reduction achieved in the MMC group. (C) 2013 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rosentreter, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaki, Stergiani UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450649
DOI:	10.1159/000356400
Journal or Publication Title:	Ophthalmologica
Volume:	231
Number:	3
Page Range:	S. 133 - 141
Date:	2014
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0267
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLLAGEN MATRIX IMPLANT; GLAUCOMA; OLOGEN; 5-FLUOROURACIL Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45064