Universität zu Köln

Cordes, J., Wittersheim, M., Harder, J. and Glaeser, R. (2014). The skin's own antibiotics. Important features of antimicrobial peptides for clinical practice. Hautarzt, 65 (1). S. 50 - 56. NEW YORK: SPRINGER. ISSN 1432-1173

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Abstract

Despite permanent confrontation with a potentially harmful environment, its own microbiota and the fact that minor injuries occur frequently in everyday life, skin infections are a rare event. A chemical barrier of antimicrobial peptides (AMP), some of them constitutively expressed, others inducible by various stimuli, contributes to the integument's resistance. AMP are evolutionarily old components of the innate immunity which became the focus of interest due to their broad spectrum of activity against microorganisms and the rare occurrence of antimicrobial resistance. These attributes make them promising alternative candidates for future antibiotics. Furthermore various dermatological diseases are associated with an altered expression of these molecules, which might then play a pathogenetic role. In addition to their antimicrobial activity, some AMP have immunomodulatory effects and can promote wound healing, properties which currently are under intensive research.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cordes, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittersheim, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Harder, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Glaeser, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450937
DOI:	10.1007/s00105-013-2638-6
Journal or Publication Title:	Hautarzt
Volume:	65
Number:	1
Page Range:	S. 50 - 56
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1173
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MESSENGER-RNA EXPRESSION; SQUAMOUS-CELL CARCINOMA; HEALTHY-HUMAN SKIN; ATOPIC-DERMATITIS; INNATE IMMUNITY; DIFFERENTIAL EXPRESSION; STAPHYLOCOCCUS-AUREUS; HUMAN BETA-DEFENSIN-3; HUMAN KERATINOCYTES; PSORIASIN S100A7 Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45093