Universität zu Köln

Dogan, S., Astvatsatourov, A., Deserno, T. M., Bock, F., Shah-Hosseini, K., Michels, A. and Moesges, R. (2014). Objectifying the Conjunctival Provocation Test: Photography-Based Rating and Digital Analysis. Int. Arch. Allergy Immunol., 163 (1). S. 59 - 69. BASEL: KARGER. ISSN 1423-0097

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Abstract

Background: Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no international guidelines defining the CPT. No approved evaluation method exists for interpreting CPT results. This paper aims to establish the digital analysis of macroimages as an objective, validated and standardized method for interpreting CPT results. Methods: In a clinical immunotherapy trial with 155 patients, treatment progress was documented based on the CPT. Local investigators used a symptom score to grade tearing, reddening and the patients' subjective perception of symptoms (mucosal irritation). A central observer rated conjunctival hyperemia via digital photography. Digital image analysis software was utilized to determine conjunctival hyperemia. Results: Spearman's correlation between the local investigators' and the central observer's ratings was r = 0.729 (p < 0.001); the percentage of total agreement was 48% (based on 739 photos). Digital image analysis (based on 48 photos) had a high percentage of total agreement with the central observer's ratings (69%) but a low percentage of total agreement with the investigators' ratings (38%). The corresponding correlations were r = 0.264 and 0.064, respectively. Conclusion: Photography-based rating by a central observer may represent a valuable supplement to the local investigator's assessment for making an objective evaluation of CPT results. Digital image analysis possesses the potential of being an objective evaluation method compared to the wide-spread subjective evaluation by the investigators. (C) 2013 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dogan, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Astvatsatourov, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Deserno, T. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah-Hosseini, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesges, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-451186
DOI:	10.1159/000355333
Journal or Publication Title:	Int. Arch. Allergy Immunol.
Volume:	163
Number:	1
Page Range:	S. 59 - 69
Date:	2014
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0097
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALLERGEN CHALLENGE; IMAGE-ANALYSIS; UPPER AIRWAYS; SKIN PRICK; QUANTIFICATION; GUIDELINES; HISTAMINE; RHINITIS; RHINOCONJUNCTIVITIS; SENSITIVITY Multiple languages Allergy; Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45118