Universität zu Köln

Krug, A., Cabanis, M., Pyka, M., Pauly, K., Kellermann, T., Walter, H., Wagner, M., Landsberg, M., Shah, N. J., Winterer, G., Woelwer, W., Brinkmeyer, J., Mueller, B. W., Kaergel, C., Wiedemann, G., Herrlich, J., Vogeley, K., Schilbach, L., Rapp, A., Klingberg, S. and Kircher, T. (2014). Attenuated prefrontal activation during decision-making under uncertainty in schizophrenia: A multi-center fMRI study. Schizophr. Res., 152 (1). S. 176 - 184. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1573-2509

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Abstract

Decisions are called decisions under uncertainty when either prior information is incomplete or the outcomes of the decision are unclear. Alterations in these processes related to decisions under uncertainty have been linked to delusions. In patients with schizophrenia, the underlying neural networks have only rarely been studied. We aimed to disentangle the neural correlates of decision-making and relate them to neuropsychological and psychopathological parameters in a large sample of patients with schizophrenia and healthy subjects. Fifty-seven patients and fifty-seven healthy volunteers from six centers had to either indicate via button-press from which of two bottles red or blue balls were drawn (decision-making under uncertainty condition), or indicate whether eight red balls had been presented (baseline condition) while BOLD signal was measured with fMRI. Patients based their decisions on less conclusive evidence and had decreased activations in the underlying neural network, comprising of medial and lateral frontal as well as parietal areas, as compared to healthy subjects. While current psychopathology was not correlated with brain activation, positive symptoms led to longer decision latencies in patients. These results suggest that decision-making under uncertainty in schizophrenia is affected by a complex interplay of aberrant neural activation. Furthermore, reduced neuropsychological functioning in patients was related to impaired decision-making and task performance was modulated by distinct positive symptoms. (C) 2013 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Krug, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cabanis, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pyka, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauly, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kellermann, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Landsberg, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, N. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Winterer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Woelwer, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinkmeyer, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, B. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaergel, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiedemann, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrlich, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogeley, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rapp, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingberg, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kircher, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-451265
DOI:	10.1016/j.schres.2013.11.007
Journal or Publication Title:	Schizophr. Res.
Volume:	152
Number:	1
Page Range:	S. 176 - 184
Date:	2014
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1573-2509
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEGATIVE-SYNDROME-SCALE; WORKING-MEMORY TASK; CONCLUSIONS BIAS; HEALTHY-INDIVIDUALS; BRAIN ACTIVATION; 5-FACTOR MODEL; PSYCHOSIS; PERFORMANCE; DELUSIONS; CORTEX Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45126