Universität zu Köln

Soellner, Isabel A., Rabe, Jennifer, Mauri, Victor, Kaufmann, Janina, Addicks, Klaus and Kuerten, Stefanie (2013). Differential aspects of immune cell infiltration and neurodegeneration in acute and relapse experimental autoimmune encephalomyelitis. Clin. Immunol., 149 (3). S. 519 - 530. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1521-7035

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Abstract

Proteolipid protein (PLP)-induced experimental autoimmune encephalomyelitis (EAE) in SJL/J mice is a well-established animal model for the study of relapsing remitting multiple sclerosis (MS). Here we investigated histomorphological differences between acute and relapse EAE in order to get further insights into the mechanisms that trigger the transition from a relapsing remitting course to chronic-progressive disease. We found the extent of inflammation to differ in respect to the type of immune cells infiltrating the CNS and the manifestation of edema. Myelin pathology was predominated by demyelinated axons in the acute phase. In relapse EAE the extent of myelin pathology declined and was characterized by a balance between demyelinated and demyelinating nerve fibers. Axonal pathology increased with disease progression and was partly separated from myelin pathology and inflammation. The reported incisive differences between acute and relapse EAE suggest a transition from inflammatory processes to independent neurodegeneration in the disease course. (C) 2013 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Soellner, Isabel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabe, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauri, Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaufmann, Janina UNSPECIFIED UNSPECIFIED UNSPECIFIED Addicks, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuerten, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470567
DOI:	10.1016/j.clim.2013.10.011
Journal or Publication Title:	Clin. Immunol.
Volume:	149
Number:	3
Page Range:	S. 519 - 530
Date:	2013
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1521-7035
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MAGNETIC-RESONANCE-SPECTROSCOPY; MULTIPLE-SCLEROSIS; AXONAL DAMAGE; MITOCHONDRIAL DYSFUNCTION; MEDICAL PROGRESS; NERVOUS-SYSTEM; SCHWANN-CELLS; ANIMAL-MODELS; G-RATIO Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47056