Universität zu Köln

Jensen, Karin B., Srinivasan, Priti, Spaeth, Rosa, Tan, Ying, Kosek, Eva, Petzke, Frank, Carville, Serena, Fransson, Peter ORCID: 0000-0002-1305-9875, Marcus, Hanke, Williams, Steven C. R., Choy, Ernest, Vitton, Olivier, Gracely, Richard, Ingvar, Martin ORCID: 0000-0002-9041-5714 and Kong, Jian (2013). Overlapping Structural and Functional Brain Changes in Patients With Long-Term Exposure to Fibromyalgia Pain. Arthritis Rheum., 65 (12). S. 3293 - 3304. HOBOKEN: WILEY. ISSN 1529-0131

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Abstract

ObjectiveThere is vast evidence to support the presence of brain aberrations in patients with fibromyalgia (FM), and it is possible that central plasticity is critical for the transition from acute to chronic pain. The aim of the present study was to investigate the relationship between brain structure and function in patients with FM. MethodsFunctional connectivity of the brain during application of intermittent pressure-pain stimuli and measures of brain structure were compared between 26 patients with FM and 13 age- and sex-matched healthy controls. Magnetic resonance imaging (MRI) was performed to obtain high-resolution anatomic images and functional MRI scans of the brain, which were used for measurements of pain-evoked brain activity. ResultsFM patients displayed a distinct overlap between decreased cortical thickness, decreased brain volumes, and decreased functional regional coherence in the rostral anterior cingulate cortex. The morphometric changes were more pronounced with longer exposure to FM pain. In addition, there was evidence of an association between structural and functional changes in the mesolimbic areas of the brain and the severity of comorbid depression symptoms in FM patients. ConclusionThe combined integration of structural and functional measures allowed for a unique characterization of the impact of FM pain on the brain. These data may lead to the identification of early structural and functional brain alterations in response to pain, which could be used to develop markers for predicting the development of FM and other pain disorders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jensen, Karin B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Srinivasan, Priti UNSPECIFIED UNSPECIFIED UNSPECIFIED Spaeth, Rosa UNSPECIFIED UNSPECIFIED UNSPECIFIED Tan, Ying UNSPECIFIED UNSPECIFIED UNSPECIFIED Kosek, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Petzke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Carville, Serena UNSPECIFIED UNSPECIFIED UNSPECIFIED Fransson, Peter UNSPECIFIED orcid.org/0000-0002-1305-9875 UNSPECIFIED Marcus, Hanke UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, Steven C. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Choy, Ernest UNSPECIFIED UNSPECIFIED UNSPECIFIED Vitton, Olivier UNSPECIFIED UNSPECIFIED UNSPECIFIED Gracely, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Ingvar, Martin UNSPECIFIED orcid.org/0000-0002-9041-5714 UNSPECIFIED Kong, Jian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-471333
DOI:	10.1002/art.38170
Journal or Publication Title:	Arthritis Rheum.
Volume:	65
Number:	12
Page Range:	S. 3293 - 3304
Date:	2013
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1529-0131
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SURFACE-BASED ANALYSIS; REGIONAL HOMOGENEITY; WIDESPREAD PAIN; CLINICAL PAIN; CONNECTIVITY; SENSITIVITY; ABNORMALITIES; SEGMENTATION; RELIABILITY; PERCEPTION Multiple languages Rheumatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47133