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Hallek, Michael (2013). Signaling the end of chronic lymphocytic leukemia: new frontline treatment strategies. Blood, 122 (23). S. 3723 - 3735. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

The management of chronic lymphocytic leukemia (CLL) is undergoing profound changes. Several new drugs have been approved for CLL treatment (fludarabine, bendamustine, and the monoclonal antibodies alemtuzumab, rituximab, and ofatumumab) and many more drugs are in advanced clinical development to be approved for this disease. In addition, the extreme heterogeneity of the clinical course and our improved ability to foresee the prognosis of this leukemia by the use of clinical, biological, and genetic parameters now allow us to characterize patients with a very mild onset and course, an intermediate prognosis, or a very aggressive course with high-risk leukemia. Therefore, it becomes increasingly challenging to select the right treatment strategy for each condition. This article summarizes the currently available diagnostic and therapeutic tools and gives an integrated recommendation of how to manage CLL in 2013. Moreover, I propose a strategy how we might integrate the novel agents for CLL therapy into sequential treatment approaches in the near future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-471750
DOI:	10.1182/blood-2013-05-498287
Journal or Publication Title:	Blood
Volume:	122
Number:	23
Page Range:	S. 3723 - 3735
Date:	2013
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREVIOUSLY UNTREATED PATIENTS; FLUDARABINE PLUS CYCLOPHOSPHAMIDE; PHASE-II TRIAL; 1ST-LINE THERAPY; MONOCLONAL-ANTIBODY; ANTI-CD20 ANTIBODY; MAMMALIAN TARGET; RITUXIMAB; ALEMTUZUMAB; COMBINATION Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47175