Universität zu Köln

Florin, Esther ORCID: 0000-0001-8276-2508, Mueller, Desiree, Pfeifer, Johannes ORCID: 0000-0002-6756-6418, Barbe, Michael T., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Timmermann, Lars (2013). Subthalamic stimulation modulates self-estimation of patients with Parkinson's disease and induces risk-seeking behaviour. Brain, 136. S. 3271 - 3282. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2156

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Abstract

Patients with Parkinson's disease with deep brain stimulation in the subthalamic nucleus postoperatively often display higher impulsivity and therefore may experience difficulties in social interactions. Here, we examined social interactions of patients with Parkinson's disease with and without deep brain stimulation in the subthalamic nucleus in competitive situations. We hypothesized altered self-estimation and risk-seeking behaviour in this patient group induced by deep brain stimulation in the subthalamic nucleus. To test the hypothesis, an experimental setting was used in which participants performed a calculation task and chose their preferred compensation. Based on their actual calculation performance, more patients with Parkinson's disease with deep brain stimulation chose a competitive tournament compensation. Assuming rational behaviour, this self-selection pattern reflects increased risk tolerance. Since patients who performed in the lowest quartile chose the tournament option, the data suggest that deep brain stimulation in the subthalamic nucleus results in a loss of the correct reference frame against which patients with Parkinson's disease evaluate their performance. The stimulation-induced combination of overestimation of their own performance, increased risk-taking, and preference for competitive environments despite poor performance is likely to impact considerably on the patients' social and work life.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Florin, Esther UNSPECIFIED orcid.org/0000-0001-8276-2508 UNSPECIFIED Mueller, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeifer, Johannes UNSPECIFIED orcid.org/0000-0002-6756-6418 UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-473315
DOI:	10.1093/brain/awt241
Journal or Publication Title:	Brain
Volume:	136
Page Range:	S. 3271 - 3282
Date:	2013
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2156
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; IMPAIRED DECISION-MAKING; NUCLEUS; DOPAMINE; REWARD; OVERCONFIDENCE; CONNECTIVITY; RATIONALITY; IMPULSIVITY; ACTIVATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47331