Koutsouleris, N., Ruhrmann, S., Falkai, P. and Maier, W. (2013). Personalised medicine in psychiatry and psychotherapy. A review of the current state-of-the-art in the biomarker-based early recognition of psychoses. Bundesgesundheitsblatt-Gesund., 56 (11). S. 1522 - 1531. NEW YORK: SPRINGER. ISSN 1437-1588

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Abstract

The main goal of psychiatric high-risk research-the personalised early recognition and intervention of schizophrenic and affective psychoses-is one of the biggest challenges of current clinical psychiatry due to the immense socioeconomic burden of these disorders. In this regard, this review discusses the prospects and caveats of new clinical, neuropsychological, neurophysiological and imaging-based concepts aimed at optimising the current state-of-the-art of early recognition. Finally, multivariate modelling and machine learning methods are presented as a novel methodological framework facilitating the decoding of early psychosis into different intermediate phenotypes. In the future, these phenotypes could be employed for a more objective risk stratification that operates at the single-subject level. This could allow us to generate clinically applicable prognostic biomarkers for these disorders that would propel the individualised prevention of disease transition, chronification and psychopharmacological treatment resistance of psychotic disorders.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Koutsouleris, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falkai, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-473326
DOI: 10.1007/s00103-013-1840-0
Journal or Publication Title: Bundesgesundheitsblatt-Gesund.
Volume: 56
Number: 11
Page Range: S. 1522 - 1531
Date: 2013
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1437-1588
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ULTRA-HIGH-RISK; STRUCTURAL BRAIN ALTERATIONS; SCHIZOPHRENIA-PATIENTS; 1ST-EPISODE PSYCHOSIS; MISMATCH NEGATIVITY; HEALTHY CONTROLS; MENTAL STATE; ONSET; METAANALYSIS; PEOPLEMultiple languages
Public, Environmental & Occupational HealthMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47332

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