Universität zu Köln

Rueger, Maria Adele and Androutsellis-Theotokis, Andreas (2013). Identifying Endogenous Neural Stem Cells in the Adult Brain In Vitro and In Vivo: Novel Approaches. Curr. Pharm. Design, 19 (36). S. 6499 - 6507. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1873-4286

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Abstract

In the 1960s, Joseph Altman reported that the adult mammalian brain is capable of generating new neurons. Today it is understood that some of these neurons are derived from uncommitted cells in the subventricular zone lining the lateral ventricles, and the dentate gyrus of the hippocampus. The first area generates new neuroblasts which migrate to the olfactory bulb, whereas hippocampal neurogenesis seems to play roles in particular types of learning and memory. A part of these uncommitted (immature) cells is able to divide and their progeny can generate all three major cell types of the nervous system: neurons, astrocytes, and oligodendrocytes; these properties define such cells as neural stem cells. Although the roles of these cells are not yet clear, it is accepted that they affect functions including olfaction and learning/memory. Experiments with insults to the central nervous system also show that neural stem cells are quickly mobilized due to injury and in various disorders by proliferating, and migrating to injury sites. This suggests a role of endogenous neural stem cells in disease. New pools of stem cells are being discovered, suggesting an even more important role for these cells. To understand these cells and to coax them to contribute to tissue repair it would be very useful to be able to image them in the living organism. Here we discuss advances in imaging approaches as well as new concepts that emerge from stem cell biology with emphasis on the interface between imaging and stem cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rueger, Maria Adele UNSPECIFIED UNSPECIFIED UNSPECIFIED Androutsellis-Theotokis, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-473381
DOI:	10.2174/1381612811319360010
Journal or Publication Title:	Curr. Pharm. Design
Volume:	19
Number:	36
Page Range:	S. 6499 - 6507
Date:	2013
Publisher:	BENTHAM SCIENCE PUBL LTD
Place of Publication:	SHARJAH
ISSN:	1873-4286
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL-NERVOUS-SYSTEM; FIBROBLAST GROWTH FACTOR-2; FOCAL CEREBRAL-ISCHEMIA; PROGENITOR CELLS; HIPPOCAMPAL NEUROGENESIS; DENTATE GYRUS; SUBVENTRICULAR ZONE; LATERAL INHIBITION; MAMMALIAN FOREBRAIN; DIRECTED MIGRATION Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47338