Universität zu Köln

Lilue, Jingtao ORCID: 0000-0002-1958-0231, Mueller, Urs Benedikt, Steinfeldt, Tobias and Howard, Jonathan C. (2013). Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse. eLife, 2. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lilue, Jingtao UNSPECIFIED orcid.org/0000-0002-1958-0231 UNSPECIFIED Mueller, Urs Benedikt UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinfeldt, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Howard, Jonathan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-473788
DOI:	10.7554/eLife.01298
Journal or Publication Title:	eLife
Volume:	2
Date:	2013
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GTPASES; IMMUNITY; FAMILY; MICE; SEQUENCE; SUSCEPTIBILITY; COEVOLUTION; LRG-47; GROWTH; GENES Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47378