Universität zu Köln

Herbrecht, R., Cernohous, P., Engert, A., Le Gouill, S., Macdonald, D., Machida, C., Myint, H., Saleh, A., Singer, J., Wilhelm, M. and van der Jagt, R. (2013). Comparison of pixantrone-based regimen (CPOP-R) with doxorubicin-based therapy (CHOP-R) for treatment of diffuse large B-cell lymphoma. Ann. Oncol., 24 (10). S. 2618 - 2624. OXFORD: OXFORD UNIV PRESS. ISSN 0923-7534

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Abstract

Pixantrone is an aza-anthracenedione with enhanced, preclinical antitumor activity and reduced cardiotoxicity compared with doxorubicin. We compared the efficacy and toxic effect of CPOP-R (substituting pixantrone for doxorubicin) against CHOP-R in untreated, diffuse large B-cell lymphoma (DLBCL) patients. The primary objective was to demonstrate non-inferiority of CPOP-R by complete response/complete response unconfirmed (CR/CRu) rate. The CR/CRu rate for CPOP-R was 75% versus 84% for CHOP-R. Three-year overall survival was lower for CPOP-R (69% versus 85%) (P = 0.029). Median progression-free survival (PFS) was not reached for CPOP-R and was 40 months for CHOP-R [HR 95% confidence interval (CI) = 1.02 (0.60, 1.76), P = 0.934]. Fewer CPOP-R patients developed congestive heart failure (CHF) (0% versus 6%, P = 0.120), >= 20% declines in ejection fraction (2% versus 17%, P = 0.004), or elevations in troponin-T (P = 0.003). CPOP-R is an active regimen with modestly lower response rates than CHOP-R but similar PFS and event-free survival. This study demonstrates a substantially lower cardiotoxicity of pixantrone compared with doxorubicin when used as first-line therapy in DLBCL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herbrecht, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cernohous, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le Gouill, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Macdonald, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Machida, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Myint, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saleh, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Singer, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilhelm, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Jagt, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475240
DOI:	10.1093/annonc/mdt289
Journal or Publication Title:	Ann. Oncol.
Volume:	24
Number:	10
Page Range:	S. 2618 - 2624
Date:	2013
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	0923-7534
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NON-HODGKINS-LYMPHOMA; ELDERLY-PATIENTS; INTENSIVE CHEMOTHERAPY; AZA-ANTHRACENEDIONE; CYCLOPHOSPHAMIDE; VINCRISTINE; PREDNISONE; BBR-2778 Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47524