Universität zu Köln

Piroth, Marc D., Liebenstund, Sarah, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Shah, Nadim J., Eble, Michael J., Coenen, Heinz H. ORCID: 0000-0002-3810-103X and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2013). Monitoring of Radiochemotherapy in Patients with Glioblastoma Using O-(2-[F-18]Fluoroethyl)-L-Tyrosine Positron Emission Tomography: Is Dynamic Imaging Helpful? Mol. Imaging, 12 (6). HAMILTON: B C DECKER INC. ISSN 1536-0121

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Abstract

Monitoring of radiochemotherapy (RCX) in patients with glioblastoma is difficult because unspecific alterations in magnetic resonance imaging with contrast enhancement can mimic tumor progression. Changes in tumor to brain ratios (TBRs) in positron emission tomography (PET) using O-(2-[F-18]fluoroethyl)-L-tyrosine (F-18-FET) after RCX with temozolomide of patients with glioblastoma have been shown to be valuable parameters to predict survival. The kinetic behavior of F-18-FET in the tumors is another promising parameter to analyze tumor metabolism. In this study, we investigated the predictive value of dynamic F-18-FET PET during RCX of glioblastoma. Time-activity curves (TACs) of F-18-FET uptake of 25 patients with glioblastoma were evaluated after surgery (FET-1), early (7-10 days) after completion of RCX (FET-2), and 6 to 8 weeks later (FET-3). Changes in the time to peak (TTP) and the slope of the TAC (10-50 minutes postinjection) were analyzed and related to survival. Changes in kinetic parameters of F-18-FET uptake after RCX showed no relationship with survival time. In contrast, the high predictive value of changes of TBR to predict survival was confirmed. We conclude that dynamic F-18-FET PET does not provide additional prognostic information during RCX. Static F-18-FET PET imaging (20-40 minutes postinjection) appears to be sufficient for this purpose and reduces costs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Piroth, Marc D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebenstund, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eble, Michael J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Coenen, Heinz H. UNSPECIFIED orcid.org/0000-0002-3810-103X UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476193
DOI:	10.2310/7290.2013.00056
Journal or Publication Title:	Mol. Imaging
Volume:	12
Number:	6
Date:	2013
Publisher:	B C DECKER INC
Place of Publication:	HAMILTON
ISSN:	1536-0121
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RADIOLABELED AMINO-ACIDS; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; MALIGNANT GLIOMA; CEREBRAL GLIOMAS; BRAIN-TUMORS; FET PET; MRI; NECROSIS Multiple languages Biochemical Research Methods; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47619