Schumacher, B. (2012). DNA repair and the aging process. Med. Genet., 24 (4). S. 289 - 296. NEW YORK: SPRINGER. ISSN 1863-5490
Full text not available from this repository.Abstract
Recent years have witnessed substantial progress in the understanding of the biology of aging. The significance of genomic instability as a causal factor in age-related functional decline has become particularly apparent through research into progeria syndromes. Human progeria syndromes are rare hereditary genetic disorders that are characterized by enormous diversity and complexity. The clinical manifestations of progeria syndromes reflect both the functions of the genome maintenance mechanisms involved, as well as the complex physiological adjustments that are evoked by lesions in the DNA. Investigation of biological model systems of progeria syndromes has revealed links between the DNA damage response and the genetic mechanisms that regulate longevity. The insights gained here have not only deepened the mechanistic understanding of the causes of progeria and aging, but have also prompted new concepts for the development of interventional strategies for the treatment of progeria syndromes and aging-related diseases.
| Item Type: | Journal Article | ||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-477343 | ||||||||
| DOI: | 10.1007/s11825-012-0352-x | ||||||||
| Journal or Publication Title: | Med. Genet. | ||||||||
| Volume: | 24 | ||||||||
| Number: | 4 | ||||||||
| Page Range: | S. 289 - 296 | ||||||||
| Date: | 2012 | ||||||||
| Publisher: | SPRINGER | ||||||||
| Place of Publication: | NEW YORK | ||||||||
| ISSN: | 1863-5490 | ||||||||
| Language: | German | ||||||||
| Faculty: | Unspecified | ||||||||
| Divisions: | Unspecified | ||||||||
| Subjects: | no entry | ||||||||
| Uncontrolled Keywords: |
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/47734 |
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