Universität zu Köln

Ladage, Dennis ORCID: 0000-0002-4512-0917, Braunroth, Christian, Lenzen, Edward, Berghoefer, Sandra, Graf, Christine, Bloch, Wilhelm and Brixius, Klara (2012). Influence of intermittent hypoxia interval training on exercise-dependent erythrocyte NOS activation and blood pressure in diabetic patients. Can. J. Physiol. Pharmacol., 90 (12). S. 1591 - 1599. OTTAWA: CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS. ISSN 0008-4212

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Abstract

NOS-activation in erythrocytes (eryNOS) is impaired in patients suffering from type 2 diabetes. We investigated the effect of physical exercise on eryNOS activation and whether 6 week hypoxia interval training may alter this process. Male patients with diabetes mellitus type 2 (NIDDM, n = 12; age, 61.3 +/- 8.4 years; BMI, 29.8 +/- 3.7 kg/m(2)) underwent physical exercise training before and after 6 week hypoxia interval training. Training was conducted 4 times per week for 90 min at 15.4 -12.7 Vol% of inspired oxygen. Vital parameters were recorded. Before hypoxia intervention, eryNOS phosphorylation at serine(1177) decreased significantly during exercise (basal 17.4 +/- 12.0 compared with exercise 8.4 +/- 9.2 arbitrary grey values (arGV); P < 0.05). After 6 weeks of hypoxia intervention, eryNOS-pSer(1177) (2.2 +/- 2.5 arGV) was significantly lower at baseline. Ergometry showed an increase (7.6 +/- 3.0 arGV; P < 0.05) followed by a decrease to almost baseline levels after 30 min (3.8 +/- 1.5 arGV). Maximal exercise capacity and O-2-uptake ((V) over dotO(2) max) increased significantly. The effects were independent from exercise-induced elevation of blood pressure. Exercise-dependent eryNOS phosphorylation at serine1177 was increased similar to that described for the endothelium in diabetic patients. EryNOS dysregulation was partially restored after intermittent hypoxia training.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ladage, Dennis UNSPECIFIED orcid.org/0000-0002-4512-0917 UNSPECIFIED Braunroth, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenzen, Edward UNSPECIFIED UNSPECIFIED UNSPECIFIED Berghoefer, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Brixius, Klara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-477482
DOI:	10.1139/y2012-138
Journal or Publication Title:	Can. J. Physiol. Pharmacol.
Volume:	90
Number:	12
Page Range:	S. 1591 - 1599
Date:	2012
Publisher:	CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
Place of Publication:	OTTAWA
ISSN:	0008-4212
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NITRIC-OXIDE SYNTHASE; ENDOTHELIAL-CELL DYSFUNCTION; PHOSPHORYLATION SITES; MOLECULAR-MECHANISMS; OXIDATIVE STRESS; GENE-EXPRESSION; PROTEIN-KINASE; L-ARGININE; FLOW; ALTITUDE Multiple languages Pharmacology & Pharmacy; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47748