Universität zu Köln

Hammel, Matthias and Deska, Jan ORCID: 0000-0003-4622-2365 (2012). Enantioselective Synthesis of Axially Chiral Tetrasubstituted Allenes via Lipase-Catalyzed Desymmetrization. Synthesis, 44 (24). S. 3789 - 3797. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1437-210X

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Abstract

Lipase from Pseudomonas fluorescens efficiently catalyzes the transesterification of prochiral tetrasubstituted allenic diols yielding highly enantioenriched axially chiral allenyl monoesters. In combination with subsequent 5-endo-trig cyclizations geminally disubstituted dihydrofurans are accessible in high optical purity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hammel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Deska, Jan UNSPECIFIED orcid.org/0000-0003-4622-2365 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-477573
DOI:	10.1055/s-0032-1317524
Journal or Publication Title:	Synthesis
Volume:	44
Number:	24
Page Range:	S. 3789 - 3797
Date:	2012
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1437-210X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEREOSELECTIVE-SYNTHESIS; KINETIC RESOLUTION; ENZYMES Multiple languages Chemistry, Organic Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47757