Kaehler, Christian, Isensee, Joerg ORCID: 0000-0002-3390-0051, Nonhoff, Ute, Terrey, Markus
ORCID: 0000-0002-7359-4810, Hucho, Tim
ORCID: 0000-0002-4147-9308, Lehrach, Hans and Krobitsch, Sylvia
(2012).
Ataxin-2-Like Is a Regulator of Stress Granules and Processing Bodies.
PLoS One, 7 (11).
SAN FRANCISCO:
PUBLIC LIBRARY SCIENCE.
ISSN 1932-6203
Abstract
Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis. For the disease-causing protein in spinocerebellar ataxia type 2, ataxin-2, a paralog of unknown function, termed ataxin-2-like, has been described. We discovered that ataxin-2-like associates with known interaction partners of ataxin-2, the RNA helicase DDX6 and the poly(A)-binding protein, and with ataxin-2 itself. Furthermore, we found that ataxin-2-like is a component of stress granules. Interestingly, sole ataxin-2-like overexpression led to the induction of stress granules, while a reduction of stress granules was detected in case of a low ataxin-2-like level. Finally, we observed that overexpression of ataxin-2-like as well as its reduction has an impact on the presence of microscopically visible processing bodies. Thus, our results imply a functional overlap between ataxin-2-like and ataxin-2, and further indicate a role for ataxin-2-like in the regulation of stress granules and processing bodies.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-478382 | ||||||||||||||||||||||||||||||||
DOI: | 10.1371/journal.pone.0050134 | ||||||||||||||||||||||||||||||||
Journal or Publication Title: | PLoS One | ||||||||||||||||||||||||||||||||
Volume: | 7 | ||||||||||||||||||||||||||||||||
Number: | 11 | ||||||||||||||||||||||||||||||||
Date: | 2012 | ||||||||||||||||||||||||||||||||
Publisher: | PUBLIC LIBRARY SCIENCE | ||||||||||||||||||||||||||||||||
Place of Publication: | SAN FRANCISCO | ||||||||||||||||||||||||||||||||
ISSN: | 1932-6203 | ||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/47838 |
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