Universität zu Köln

Masjkur, Jimmy, Rueger, Maria Adele, Bornstein, Stefan R., McKay, Ron and Androutsellis-Theotokis, Andreas (2012). Neurovascular Signals Suggest a Propagation Mechanism for Endogenous Stem Cell Activation Along Blood Vessels. CNS Neurol. Disord.-Drug Targets, 11 (7). S. 805 - 818. BUSUM: BENTHAM SCIENCE PUBL. ISSN 1996-3181

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Abstract

Stem cell - based therapies for central nervous system disorders are intensely pursued. Such approaches can be divided into two categories: Transplantation-based, and those that aim to pharmacologically target the endogenous stem cell population in the tissue. Endogenous stem cell - based strategies avoid the problem of immune incompatibility between the host and the grafted cells. They also avoid the placement of a large amount of cells in confined areas, a manipulation which alters the characteristics of the neurovascular microenvironment. We show here that massive pharmacological activation (increase in cell numbers) of the endogenous neural stem cell population in the adult rodent brain maintains the cytoarchitecture of the neurovascular niche. Distances between adjacent stem cells (identified by expression of Hes3) are maintained above a minimum. Hes3+ cells maintain their physical association with blood vessels. These results also suggest a mechanism by which the activation signal from the lateral ventricle can be propagated to areas a long distance away from the lateral ventricles, through autocrine/paracrine actions between adjacent Hes3+ cells, along blood vessels. Finally, powerful effects of angiopoietin 2 on Hes3+ cells help explain the prevalence of proliferating endogenous neural stem cells close to the subventricular zone (an area of high angiopoietin 2 concentration) and the quiescent state of stem cells away from the ventricles and their tight physical association with blood vessels (which express high levels of angiopoietin 1, a cytokine that opposes angiopoietin 2 functions).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Masjkur, Jimmy UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueger, Maria Adele UNSPECIFIED UNSPECIFIED UNSPECIFIED Bornstein, Stefan R. UNSPECIFIED UNSPECIFIED UNSPECIFIED McKay, Ron UNSPECIFIED UNSPECIFIED UNSPECIFIED Androutsellis-Theotokis, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479369
DOI:	10.2174/1871527311201070805
Journal or Publication Title:	CNS Neurol. Disord.-Drug Targets
Volume:	11
Number:	7
Page Range:	S. 805 - 818
Date:	2012
Publisher:	BENTHAM SCIENCE PUBL
Place of Publication:	BUSUM
ISSN:	1996-3181
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL-NERVOUS-SYSTEM; ADULT-MOUSE BRAIN; NEUROGENESIS IN-VITRO; SUBVENTRICULAR ZONE; GROWTH-FACTOR; PROGENITOR PROLIFERATION; HIPPOCAMPAL NEUROGENESIS; NEURAL PROGENITORS; SONIC HEDGEHOG; DENTATE GYRUS Multiple languages Neurosciences; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47936