Universität zu Köln

Lutz, Manfred P., Zalcberg, John R., Ducreux, Michel ORCID: 0000-0001-8649-7449, Ajani, Jaffer A., Allum, William, Aust, Daniela, Bang, Yung-Jue, Cascinu, Stefano ORCID: 0000-0003-2215-0731, Hoelscher, Arnulf, Jankowski, Janusz ORCID: 0000-0003-2130-9181, Jansen, Edwin P. M., Kisslich, Ralf, Lordick, Florian, Mariette, Christophe, Moehler, Markus, Oyama, Tsuneo, Roth, Arnaud, Rueschoff, Josef, Ruhstaller, Thomas, Seruca, Raquel ORCID: 0000-0002-8851-4166, Stahl, Michael, Sterzing, Florian, van Cutsem, Eric, van der Gaast, Ate, van Lanschot, Jan, Ychou, Marc ORCID: 0000-0001-7378-9469 and Otto, Florian (2012). Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - Differential treatment strategies for subtypes of early gastroesophageal cancer. Eur. J. Cancer, 48 (16). S. 2941 - 2954. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

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Abstract

The 1st St. Gallen EORTC Gastrointestinal Cancer Conference 2012 Expert Panel clearly differentiated treatment and staging recommendations for the various gastroesophageal cancers. For locally advanced gastric cancer (>= PT3N+), the preferred treatment modality was pre- and postoperative chemotherapy. The majority of panel members would also treat T2N+ or even T2N0 tumours with a similar approach mainly because pretherapeutic staging was considered highly unreliable. It was agreed that adenocarcinoma of the gastroesophageal junction (AEG) is classified best according to Siewert et al. Preoperative radiochemotherapy (RCT) is the preferred treatment for AEG type I and II tumours. For AEG type III, i.e. tumours which may be considered as gastric cancer, perioperative chemotherapy is the majority approach. For resectable squamous cell cancer of the oesophagus a clear majority recommended radiochemotherapy followed by surgery as optimal approach, irrespective of tumour size. In contrast, definitive RCT was judged appropriate for advanced tumours with extended lymph node involvement (N2) or for cancers of the upper oesophagus. Additional recommendations are presented on the use of endosonography, PET-CT scan and laparoscopy for staging and on the preferred approach to surgery. (c) 2012 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lutz, Manfred P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zalcberg, John R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ducreux, Michel UNSPECIFIED orcid.org/0000-0001-8649-7449 UNSPECIFIED Ajani, Jaffer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Allum, William UNSPECIFIED UNSPECIFIED UNSPECIFIED Aust, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Bang, Yung-Jue UNSPECIFIED UNSPECIFIED UNSPECIFIED Cascinu, Stefano UNSPECIFIED orcid.org/0000-0003-2215-0731 UNSPECIFIED Hoelscher, Arnulf UNSPECIFIED UNSPECIFIED UNSPECIFIED Jankowski, Janusz UNSPECIFIED orcid.org/0000-0003-2130-9181 UNSPECIFIED Jansen, Edwin P. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kisslich, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Lordick, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mariette, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED Moehler, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Oyama, Tsuneo UNSPECIFIED UNSPECIFIED UNSPECIFIED Roth, Arnaud UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueschoff, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhstaller, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Seruca, Raquel UNSPECIFIED orcid.org/0000-0002-8851-4166 UNSPECIFIED Stahl, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Sterzing, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED van Cutsem, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Gaast, Ate UNSPECIFIED UNSPECIFIED UNSPECIFIED van Lanschot, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ychou, Marc UNSPECIFIED orcid.org/0000-0001-7378-9469 UNSPECIFIED Otto, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479593
DOI:	10.1016/j.ejca.2012.07.029
Journal or Publication Title:	Eur. J. Cancer
Volume:	48
Number:	16
Page Range:	S. 2941 - 2954
Date:	2012
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1879-0852
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL-PRACTICE GUIDELINES; DIAGNOSIS; MANAGEMENT; ADENOCARCINOMA Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47959