Universität zu Köln

Sos, M. L. and Thomas, R. K. (2012). Genetic insight and therapeutic targets in squamous-cell lung cancer. Oncogene, 31 (46). S. 4811 - 4815. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5594

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Abstract

Squamous-cell lung cancer is one of the most prevalent subtypes of lung cancer worldwide and its pathogenesis is closely linked with tobacco exposure. Unfortunately, squamous-cell lung cancer patients do not benefit from major advances in the development of targeted therapeutics such as epidermal growth factor receptor (EGFR) inhibitors or anaplastic lymphoma kinase (ALK) inhibitors that show exquisite activity in lung adenocarcinomas with EGFR mutations or echinoderm microtubule associated protein like-4 (EML4)-ALK fusions, respectively. Major efforts have been launched to characterize the genomes of squamous-cell lung cancers. Among the new results emanating from these efforts are amplifications of the fibroblast growth factor receptor 1 gene and mutations of the discoidin domain receptor 2 gene as potential novel targets for the treatment of squamous-cell lung cancer patients. Here, we provide a review on these discoveries and their implications for clinical trials in squamous-cell lung cancer assessing the value of novel therapeutics addressing these targets.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sos, M. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, R. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479809
DOI:	10.1038/onc.2011.640
Journal or Publication Title:	Oncogene
Volume:	31
Number:	46
Page Range:	S. 4811 - 4815
Date:	2012
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5594
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATING MUTATIONS; NEVER-SMOKERS; PHASE-III; GEFITINIB; CARBOPLATIN; PACLITAXEL; INHIBITOR; ONCOGENE; SINGLE; GROWTH Multiple languages Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47980