Universität zu Köln

Mueller, H., Wiessmann, T. and Bechdolf, A. (2012). Interventions in People at Risk of Developing First Episode Psychosis: A Survey of Current Randomised Controlled Studies. Forschritte Neurol. Psychiatr., 80 (10). S. 570 - 580. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3522

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Abstract

Early and valid detection of the psychosis risk syndrome, and indicated prevention aim at preventing, delaying or ameliorating frank psychosis, improving current symptoms as well as emerging psychosocial disability. In a systematic literature search we identified seven completed randomised controlled trials of interventions for individuals at high risk of developing first episode psychosis. These studies evaluated antipsychotics, neuroprotective agents, cognitive behavioural and integrated treatment approaches. All trials reported advantages for specific interventions as compared to the respective control conditions (although not significant in each of the studies), which proved to be significant in the first meta-analysis of the studies. However, the current results do not allow recommendations for any specific treatment. Therefore, interventions should be thoroughly reviewed based on their risk/benefit ratio. The level of individual clinical risk, assumed benefits and side effects of interventions are critical determinants for these considerations. Future research is needed with sufficiently powered, methodologically sound replication studies, which are designed to explore differential efficacy of the interventions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiessmann, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481401
DOI:	10.1055/s-0032-1313038
Journal or Publication Title:	Forschritte Neurol. Psychiatr.
Volume:	80
Number:	10
Page Range:	S. 570 - 580
Date:	2012
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3522
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH-RISK; COGNITIVE-BEHAVIOR THERAPY; BASE-LINE CHARACTERISTICS; CONTROLLED-TRIAL; AT-RISK; 1ST-EPISODE PSYCHOSIS; INTERRATER RELIABILITY; INDICATED PREVENTION; PREDICTIVE-VALIDITY; PRODROMAL SYNDROMES Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48140