Warren, Helen, Dudbridge, Frank, Fletcher, Olivia
ORCID: 0000-0001-9387-7116, Orr, Nick, Johnson, Nichola, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Mahmoodi, Maryam, Schmidt, Marjanka K., Broeks, Annegien, Cornelissen, Sten, Braaf, Linda M., Muir, Kenneth R., Lophatananon, Artitaya, Chaiwerawattana, Arkom, Wiangnon, Surapon, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Schulz-Wendtland, Ruediger, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael
ORCID: 0000-0003-4164-5561, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Guenel, Pascal
ORCID: 0000-0002-8359-518X, Laurent-Puig, Pierre
ORCID: 0000-0001-8475-5459, Mulot, Claire, Bojesen, Stig E., Nielsen, Sune F., Flyger, Henrik, Nordestgaard, Borge G., Milne, Roger L., Benitez, Javier, Arias-Perez, Jose-Ignacio, Pilar Zamora, M., Anton-Culver, Hoda, Ziogas, Argyrios, Bernstein, Leslie, Dur, Christina Clarke, Brenner, Hermann
ORCID: 0000-0002-6129-1572, Mueller, Heiko, Arndt, Volker
ORCID: 0000-0001-9320-8684, Langheinz, Anne, Meindl, Alfons, Golatta, Michael
ORCID: 0000-0002-2605-0060, Bartram, Claus R., Schmutzler, Rita K., Brauch, Hiltrud
ORCID: 0000-0001-7531-2736, Justenhoven, Christina, Bruening, Thomas, Chang-Claude, Jenny, Wang-Gohrke, Shan, Eilber, Ursula, Doerk, Thilo, Schuermann, Peter, Bremer, Michael, Hillemanns, Peter, Nevanlinna, Heli
ORCID: 0000-0002-0916-2976, Muranen, Taru A., Aittomaki, Kristiina, Blomqvist, Carl
ORCID: 0000-0003-3041-1938, Bogdanova, Natalia, Antonenkova, Natalia, Rogov, Yuriy
ORCID: 0000-0001-8934-0754, Bermisheva, Marina, Prokofyeva, Darya, Zinnatullina, Guzel, Khusnutdinova, Elza, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Hartikainen, Jaana M., Kataja, Vesa
ORCID: 0000-0003-4846-4843, Chenevix-Trench, Georgia
ORCID: 0000-0002-1878-2587, Beesley, Jonathan
ORCID: 0000-0003-1942-325X, Chen, Xiaoqing, Lambrechts, Diether
ORCID: 0000-0002-3429-302X, Smeets, Ann, Paridaens, Robert, Weltens, Caroline, Flesch-Janys, Dieter, Buck, Katharina, Behrens, Sabine, Peterlongo, Paolo
ORCID: 0000-0001-6951-6855, Bernard, Loris, Manoukian, Siranoush, Radice, Paolo
ORCID: 0000-0001-6298-4111, Couch, Fergus J., Vachon, Celine, Wang, Xianshu, Olson, Janet, Giles, Graham
ORCID: 0000-0003-4946-9099, Baglietto, Laura
ORCID: 0000-0002-8193-7529, McLean, Cariona A., Severi, Gianluca
ORCID: 0000-0001-7157-419X, John, Esther M., Miron, Alexander, Winqvist, Robert, Pylkas, Katri
ORCID: 0000-0002-2449-0521, Jukkola-Vuorinen, Arja, Grip, Mervi, Andrulis, Irene L., Knight, Julia A., Mulligan, Anna Marie
ORCID: 0000-0002-7239-5297, Weerasooriya, Nayana, Devilee, Peter
ORCID: 0000-0002-8023-2009, Tollenaar, Robert A. E. M., Martens, John W. M., Seynaeve, Caroline M., Hooning, Maartje J., Hollestelle, Antoinette
ORCID: 0000-0003-1166-1966, Jager, Agnes, Tilanus-Linthorst, Madeleine M. A., Hall, Per, Czene, Kamila
ORCID: 0000-0002-3233-5695, Liu, Jianjun
ORCID: 0000-0002-3255-3019, Li, Jingmei
ORCID: 0000-0001-8587-7511, Cox, Angela
ORCID: 0000-0002-5138-1099, Cross, Simon S., Brock, Ian W., Reed, Malcolm W. R., Pharoah, Paul
ORCID: 0000-0001-8494-732X, Blows, Fiona M., Dunning, Alison M., Ghous-saini, Maya, Ashworth, Alan, Swerdlow, Anthony
ORCID: 0000-0001-5550-4159, Jones, Michael
ORCID: 0000-0001-7479-3451, Schoemaker, Minouk
ORCID: 0000-0001-8403-2234, Easton, Douglas F., Humphreys, Manjeet, Wang, Qin, Peto, Julian and dos-Santos-Silva, Isabel
(2012).
9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium.
Cancer Epidemiol. Biomarkers Prev., 21 (10).
S. 1783 - 1792.
PHILADELPHIA:
AMER ASSOC CANCER RESEARCH.
ISSN 1538-7755
Full text not available from this repository.
Abstract
Background: Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686). Methods: To further investigate the rs865686-breast cancer association, we conducted a replication study within the Breast Cancer Association Consortium, which comprises 37 case-control studies (48,394 cases, 50,836 controls). Results: This replication study provides additional strong evidence of an inverse association between rs865686 and breast cancer risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, P = 2.01 x 10(-29)] among women of European ancestry. There were ethnic differences in the estimated minor (G)-allele frequency among controls [0.09, 0.30, and 0.38 among, respectively, Asians, Eastern Europeans, and other Europeans; P for heterogeneity (P-het) -1.3 x 10(-143)], but no evidence of ethnic differences in per allele OR (P-het = 0.43). rs865686 was associated with estrogen receptor-positive (ER+) disease (per G-allele OR, 0.89; 95% CI, 0.86-0.91; P = 3.13 x 10(-22)) but less strongly, if at all, with ER-negative (ER+) disease (OR, 0.98; 95% CI, 0.941.02; P = 0.26; P-het = 1.16 x 10(-6)), with no evidence of independent heterogeneity by progesterone receptor or HER2 status. The strength of the breast cancer association decreased with increasing age at diagnosis, with case-only analysis showing a trend in the number of copies of the Gallele with increasing age at diagnosis (P for linear trend = 0.0095), but only among women with ER+ tumors. Conclusions: This study is the first to show that rs865686 is a susceptibility marker for ER+ breast cancer. Impact: The findings further support the view that genetic susceptibility varies according to tumor subtype. Cancer Epidemiol Biomarkers Prev; 21(10); 1783-91. (c) 2012 AACR.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Warren, Helen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dudbridge, Frank | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fletcher, Olivia | UNSPECIFIED | orcid.org/0000-0001-9387-7116 | UNSPECIFIED | Orr, Nick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Johnson, Nichola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hopper, John L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Apicella, Carmel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Southey, Melissa C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mahmoodi, Maryam | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmidt, Marjanka K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Broeks, Annegien | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cornelissen, Sten | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Braaf, Linda M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muir, Kenneth R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lophatananon, Artitaya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chaiwerawattana, Arkom | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wiangnon, Surapon | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fasching, Peter A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beckmann, Matthias W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ekici, Arif B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schulz-Wendtland, Ruediger | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sawyer, Elinor J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tomlinson, Ian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kerin, Michael | UNSPECIFIED | orcid.org/0000-0003-4164-5561 | UNSPECIFIED | Burwinkel, Barbara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Marme, Frederik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schneeweiss, Andreas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sohn, Christof | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guenel, Pascal | UNSPECIFIED | orcid.org/0000-0002-8359-518X | UNSPECIFIED | Laurent-Puig, Pierre | UNSPECIFIED | orcid.org/0000-0001-8475-5459 | UNSPECIFIED | Mulot, Claire | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bojesen, Stig E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nielsen, Sune F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Flyger, Henrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nordestgaard, Borge G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Milne, Roger L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benitez, Javier | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arias-Perez, Jose-Ignacio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pilar Zamora, M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anton-Culver, Hoda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ziogas, Argyrios | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bernstein, Leslie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dur, Christina Clarke | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brenner, Hermann | UNSPECIFIED | orcid.org/0000-0002-6129-1572 | UNSPECIFIED | Mueller, Heiko | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arndt, Volker | UNSPECIFIED | orcid.org/0000-0001-9320-8684 | UNSPECIFIED | Langheinz, Anne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meindl, Alfons | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Golatta, Michael | UNSPECIFIED | orcid.org/0000-0002-2605-0060 | UNSPECIFIED | Bartram, Claus R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmutzler, Rita K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brauch, Hiltrud | UNSPECIFIED | orcid.org/0000-0001-7531-2736 | UNSPECIFIED | Justenhoven, Christina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bruening, Thomas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang-Claude, Jenny | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang-Gohrke, Shan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eilber, Ursula | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Doerk, Thilo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schuermann, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bremer, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hillemanns, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nevanlinna, Heli | UNSPECIFIED | orcid.org/0000-0002-0916-2976 | UNSPECIFIED | Muranen, Taru A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Aittomaki, Kristiina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Blomqvist, Carl | UNSPECIFIED | orcid.org/0000-0003-3041-1938 | UNSPECIFIED | Bogdanova, Natalia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Antonenkova, Natalia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rogov, Yuriy | UNSPECIFIED | orcid.org/0000-0001-8934-0754 | UNSPECIFIED | Bermisheva, Marina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Prokofyeva, Darya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zinnatullina, Guzel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Khusnutdinova, Elza | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lindblom, Annika | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Margolin, Sara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mannermaa, Arto | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kosma, Veli-Matti | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hartikainen, Jaana M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kataja, Vesa | UNSPECIFIED | orcid.org/0000-0003-4846-4843 | UNSPECIFIED | Chenevix-Trench, Georgia | UNSPECIFIED | orcid.org/0000-0002-1878-2587 | UNSPECIFIED | Beesley, Jonathan | UNSPECIFIED | orcid.org/0000-0003-1942-325X | UNSPECIFIED | Chen, Xiaoqing | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lambrechts, Diether | UNSPECIFIED | orcid.org/0000-0002-3429-302X | UNSPECIFIED | Smeets, Ann | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Paridaens, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Weltens, Caroline | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Flesch-Janys, Dieter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Buck, Katharina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Behrens, Sabine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peterlongo, Paolo | UNSPECIFIED | orcid.org/0000-0001-6951-6855 | UNSPECIFIED | Bernard, Loris | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Manoukian, Siranoush | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Radice, Paolo | UNSPECIFIED | orcid.org/0000-0001-6298-4111 | UNSPECIFIED | Couch, Fergus J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vachon, Celine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Xianshu | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Olson, Janet | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giles, Graham | UNSPECIFIED | orcid.org/0000-0003-4946-9099 | UNSPECIFIED | Baglietto, Laura | UNSPECIFIED | orcid.org/0000-0002-8193-7529 | UNSPECIFIED | McLean, Cariona A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Severi, Gianluca | UNSPECIFIED | orcid.org/0000-0001-7157-419X | UNSPECIFIED | John, Esther M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Miron, Alexander | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Winqvist, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pylkas, Katri | UNSPECIFIED | orcid.org/0000-0002-2449-0521 | UNSPECIFIED | Jukkola-Vuorinen, Arja | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Grip, Mervi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Andrulis, Irene L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Knight, Julia A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mulligan, Anna Marie | UNSPECIFIED | orcid.org/0000-0002-7239-5297 | UNSPECIFIED | Weerasooriya, Nayana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Devilee, Peter | UNSPECIFIED | orcid.org/0000-0002-8023-2009 | UNSPECIFIED | Tollenaar, Robert A. E. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martens, John W. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Seynaeve, Caroline M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hooning, Maartje J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hollestelle, Antoinette | UNSPECIFIED | orcid.org/0000-0003-1166-1966 | UNSPECIFIED | Jager, Agnes | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tilanus-Linthorst, Madeleine M. A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hall, Per | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Czene, Kamila | UNSPECIFIED | orcid.org/0000-0002-3233-5695 | UNSPECIFIED | Liu, Jianjun | UNSPECIFIED | orcid.org/0000-0002-3255-3019 | UNSPECIFIED | Li, Jingmei | UNSPECIFIED | orcid.org/0000-0001-8587-7511 | UNSPECIFIED | Cox, Angela | UNSPECIFIED | orcid.org/0000-0002-5138-1099 | UNSPECIFIED | Cross, Simon S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brock, Ian W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Reed, Malcolm W. R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pharoah, Paul | UNSPECIFIED | orcid.org/0000-0001-8494-732X | UNSPECIFIED | Blows, Fiona M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dunning, Alison M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ghous-saini, Maya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ashworth, Alan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Swerdlow, Anthony | UNSPECIFIED | orcid.org/0000-0001-5550-4159 | UNSPECIFIED | Jones, Michael | UNSPECIFIED | orcid.org/0000-0001-7479-3451 | UNSPECIFIED | Schoemaker, Minouk | UNSPECIFIED | orcid.org/0000-0001-8403-2234 | UNSPECIFIED | Easton, Douglas F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Humphreys, Manjeet | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Qin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peto, Julian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | dos-Santos-Silva, Isabel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
|
URN: |
urn:nbn:de:hbz:38-482251 |
DOI: |
10.1158/1055-9965.EPI-12-0526 |
Journal or Publication Title: |
Cancer Epidemiol. Biomarkers Prev. |
Volume: |
21 |
Number: |
10 |
Page Range: |
S. 1783 - 1792 |
Date: |
2012 |
Publisher: |
AMER ASSOC CANCER RESEARCH |
Place of Publication: |
PHILADELPHIA |
ISSN: |
1538-7755 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
GENOME-WIDE ASSOCIATION; CONFER SUSCEPTIBILITY; COMMON VARIANTS; GENETIC RISK; IDENTIFIES 2; ALLELES; LINKAGE; 5P12; AGE | Multiple languages | Oncology; Public, Environmental & Occupational Health | Multiple languages |
|
URI: |
http://kups.ub.uni-koeln.de/id/eprint/48225 |
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