Warren, Helen, Dudbridge, Frank, Fletcher, Olivia ORCID: 0000-0001-9387-7116, Orr, Nick, Johnson, Nichola, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Mahmoodi, Maryam, Schmidt, Marjanka K., Broeks, Annegien, Cornelissen, Sten, Braaf, Linda M., Muir, Kenneth R., Lophatananon, Artitaya, Chaiwerawattana, Arkom, Wiangnon, Surapon, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Schulz-Wendtland, Ruediger, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael ORCID: 0000-0003-4164-5561, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Guenel, Pascal ORCID: 0000-0002-8359-518X, Laurent-Puig, Pierre ORCID: 0000-0001-8475-5459, Mulot, Claire, Bojesen, Stig E., Nielsen, Sune F., Flyger, Henrik, Nordestgaard, Borge G., Milne, Roger L., Benitez, Javier, Arias-Perez, Jose-Ignacio, Pilar Zamora, M., Anton-Culver, Hoda, Ziogas, Argyrios, Bernstein, Leslie, Dur, Christina Clarke, Brenner, Hermann ORCID: 0000-0002-6129-1572, Mueller, Heiko, Arndt, Volker ORCID: 0000-0001-9320-8684, Langheinz, Anne, Meindl, Alfons, Golatta, Michael ORCID: 0000-0002-2605-0060, Bartram, Claus R., Schmutzler, Rita K., Brauch, Hiltrud ORCID: 0000-0001-7531-2736, Justenhoven, Christina, Bruening, Thomas, Chang-Claude, Jenny, Wang-Gohrke, Shan, Eilber, Ursula, Doerk, Thilo, Schuermann, Peter, Bremer, Michael, Hillemanns, Peter, Nevanlinna, Heli ORCID: 0000-0002-0916-2976, Muranen, Taru A., Aittomaki, Kristiina, Blomqvist, Carl ORCID: 0000-0003-3041-1938, Bogdanova, Natalia, Antonenkova, Natalia, Rogov, Yuriy ORCID: 0000-0001-8934-0754, Bermisheva, Marina, Prokofyeva, Darya, Zinnatullina, Guzel, Khusnutdinova, Elza, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Hartikainen, Jaana M., Kataja, Vesa ORCID: 0000-0003-4846-4843, Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Beesley, Jonathan ORCID: 0000-0003-1942-325X, Chen, Xiaoqing, Lambrechts, Diether ORCID: 0000-0002-3429-302X, Smeets, Ann, Paridaens, Robert, Weltens, Caroline, Flesch-Janys, Dieter, Buck, Katharina, Behrens, Sabine, Peterlongo, Paolo ORCID: 0000-0001-6951-6855, Bernard, Loris, Manoukian, Siranoush, Radice, Paolo ORCID: 0000-0001-6298-4111, Couch, Fergus J., Vachon, Celine, Wang, Xianshu, Olson, Janet, Giles, Graham ORCID: 0000-0003-4946-9099, Baglietto, Laura ORCID: 0000-0002-8193-7529, McLean, Cariona A., Severi, Gianluca ORCID: 0000-0001-7157-419X, John, Esther M., Miron, Alexander, Winqvist, Robert, Pylkas, Katri ORCID: 0000-0002-2449-0521, Jukkola-Vuorinen, Arja, Grip, Mervi, Andrulis, Irene L., Knight, Julia A., Mulligan, Anna Marie ORCID: 0000-0002-7239-5297, Weerasooriya, Nayana, Devilee, Peter ORCID: 0000-0002-8023-2009, Tollenaar, Robert A. E. M., Martens, John W. M., Seynaeve, Caroline M., Hooning, Maartje J., Hollestelle, Antoinette ORCID: 0000-0003-1166-1966, Jager, Agnes, Tilanus-Linthorst, Madeleine M. A., Hall, Per, Czene, Kamila ORCID: 0000-0002-3233-5695, Liu, Jianjun ORCID: 0000-0002-3255-3019, Li, Jingmei ORCID: 0000-0001-8587-7511, Cox, Angela ORCID: 0000-0002-5138-1099, Cross, Simon S., Brock, Ian W., Reed, Malcolm W. R., Pharoah, Paul ORCID: 0000-0001-8494-732X, Blows, Fiona M., Dunning, Alison M., Ghous-saini, Maya, Ashworth, Alan, Swerdlow, Anthony ORCID: 0000-0001-5550-4159, Jones, Michael ORCID: 0000-0001-7479-3451, Schoemaker, Minouk ORCID: 0000-0001-8403-2234, Easton, Douglas F., Humphreys, Manjeet, Wang, Qin, Peto, Julian and dos-Santos-Silva, Isabel (2012). 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium. Cancer Epidemiol. Biomarkers Prev., 21 (10). S. 1783 - 1792. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7755

Full text not available from this repository.

Abstract

Background: Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686). Methods: To further investigate the rs865686-breast cancer association, we conducted a replication study within the Breast Cancer Association Consortium, which comprises 37 case-control studies (48,394 cases, 50,836 controls). Results: This replication study provides additional strong evidence of an inverse association between rs865686 and breast cancer risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, P = 2.01 x 10(-29)] among women of European ancestry. There were ethnic differences in the estimated minor (G)-allele frequency among controls [0.09, 0.30, and 0.38 among, respectively, Asians, Eastern Europeans, and other Europeans; P for heterogeneity (P-het) -1.3 x 10(-143)], but no evidence of ethnic differences in per allele OR (P-het = 0.43). rs865686 was associated with estrogen receptor-positive (ER+) disease (per G-allele OR, 0.89; 95% CI, 0.86-0.91; P = 3.13 x 10(-22)) but less strongly, if at all, with ER-negative (ER+) disease (OR, 0.98; 95% CI, 0.941.02; P = 0.26; P-het = 1.16 x 10(-6)), with no evidence of independent heterogeneity by progesterone receptor or HER2 status. The strength of the breast cancer association decreased with increasing age at diagnosis, with case-only analysis showing a trend in the number of copies of the Gallele with increasing age at diagnosis (P for linear trend = 0.0095), but only among women with ER+ tumors. Conclusions: This study is the first to show that rs865686 is a susceptibility marker for ER+ breast cancer. Impact: The findings further support the view that genetic susceptibility varies according to tumor subtype. Cancer Epidemiol Biomarkers Prev; 21(10); 1783-91. (c) 2012 AACR.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Warren, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dudbridge, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fletcher, OliviaUNSPECIFIEDorcid.org/0000-0001-9387-7116UNSPECIFIED
Orr, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, NicholaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Apicella, CarmelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, Melissa C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahmoodi, MaryamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Marjanka K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broeks, AnnegienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornelissen, StenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braaf, Linda M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muir, Kenneth R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lophatananon, ArtitayaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaiwerawattana, ArkomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiangnon, SuraponUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fasching, Peter A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckmann, Matthias W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ekici, Arif B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz-Wendtland, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sawyer, Elinor J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomlinson, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerin, MichaelUNSPECIFIEDorcid.org/0000-0003-4164-5561UNSPECIFIED
Burwinkel, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marme, FrederikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneeweiss, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sohn, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guenel, PascalUNSPECIFIEDorcid.org/0000-0002-8359-518XUNSPECIFIED
Laurent-Puig, PierreUNSPECIFIEDorcid.org/0000-0001-8475-5459UNSPECIFIED
Mulot, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bojesen, Stig E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nielsen, Sune F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flyger, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordestgaard, Borge G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milne, Roger L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arias-Perez, Jose-IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pilar Zamora, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anton-Culver, HodaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziogas, ArgyriosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernstein, LeslieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dur, Christina ClarkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brenner, HermannUNSPECIFIEDorcid.org/0000-0002-6129-1572UNSPECIFIED
Mueller, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arndt, VolkerUNSPECIFIEDorcid.org/0000-0001-9320-8684UNSPECIFIED
Langheinz, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meindl, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Golatta, MichaelUNSPECIFIEDorcid.org/0000-0002-2605-0060UNSPECIFIED
Bartram, Claus R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brauch, HiltrudUNSPECIFIEDorcid.org/0000-0001-7531-2736UNSPECIFIED
Justenhoven, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruening, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang-Claude, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang-Gohrke, ShanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eilber, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerk, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuermann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bremer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillemanns, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nevanlinna, HeliUNSPECIFIEDorcid.org/0000-0002-0916-2976UNSPECIFIED
Muranen, Taru A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aittomaki, KristiinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blomqvist, CarlUNSPECIFIEDorcid.org/0000-0003-3041-1938UNSPECIFIED
Bogdanova, NataliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonenkova, NataliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogov, YuriyUNSPECIFIEDorcid.org/0000-0001-8934-0754UNSPECIFIED
Bermisheva, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prokofyeva, DaryaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zinnatullina, GuzelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khusnutdinova, ElzaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindblom, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Margolin, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mannermaa, ArtoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kosma, Veli-MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartikainen, Jaana M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kataja, VesaUNSPECIFIEDorcid.org/0000-0003-4846-4843UNSPECIFIED
Chenevix-Trench, GeorgiaUNSPECIFIEDorcid.org/0000-0002-1878-2587UNSPECIFIED
Beesley, JonathanUNSPECIFIEDorcid.org/0000-0003-1942-325XUNSPECIFIED
Chen, XiaoqingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lambrechts, DietherUNSPECIFIEDorcid.org/0000-0002-3429-302XUNSPECIFIED
Smeets, AnnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paridaens, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weltens, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flesch-Janys, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buck, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behrens, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peterlongo, PaoloUNSPECIFIEDorcid.org/0000-0001-6951-6855UNSPECIFIED
Bernard, LorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manoukian, SiranoushUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radice, PaoloUNSPECIFIEDorcid.org/0000-0001-6298-4111UNSPECIFIED
Couch, Fergus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vachon, CelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, XianshuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olson, JanetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giles, GrahamUNSPECIFIEDorcid.org/0000-0003-4946-9099UNSPECIFIED
Baglietto, LauraUNSPECIFIEDorcid.org/0000-0002-8193-7529UNSPECIFIED
McLean, Cariona A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Severi, GianlucaUNSPECIFIEDorcid.org/0000-0001-7157-419XUNSPECIFIED
John, Esther M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miron, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winqvist, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pylkas, KatriUNSPECIFIEDorcid.org/0000-0002-2449-0521UNSPECIFIED
Jukkola-Vuorinen, ArjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grip, MerviUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knight, Julia A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mulligan, Anna MarieUNSPECIFIEDorcid.org/0000-0002-7239-5297UNSPECIFIED
Weerasooriya, NayanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devilee, PeterUNSPECIFIEDorcid.org/0000-0002-8023-2009UNSPECIFIED
Tollenaar, Robert A. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martens, John W. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seynaeve, Caroline M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooning, Maartje J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hollestelle, AntoinetteUNSPECIFIEDorcid.org/0000-0003-1166-1966UNSPECIFIED
Jager, AgnesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tilanus-Linthorst, Madeleine M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hall, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czene, KamilaUNSPECIFIEDorcid.org/0000-0002-3233-5695UNSPECIFIED
Liu, JianjunUNSPECIFIEDorcid.org/0000-0002-3255-3019UNSPECIFIED
Li, JingmeiUNSPECIFIEDorcid.org/0000-0001-8587-7511UNSPECIFIED
Cox, AngelaUNSPECIFIEDorcid.org/0000-0002-5138-1099UNSPECIFIED
Cross, Simon S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brock, Ian W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reed, Malcolm W. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pharoah, PaulUNSPECIFIEDorcid.org/0000-0001-8494-732XUNSPECIFIED
Blows, Fiona M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunning, Alison M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghous-saini, MayaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ashworth, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Swerdlow, AnthonyUNSPECIFIEDorcid.org/0000-0001-5550-4159UNSPECIFIED
Jones, MichaelUNSPECIFIEDorcid.org/0000-0001-7479-3451UNSPECIFIED
Schoemaker, MinoukUNSPECIFIEDorcid.org/0000-0001-8403-2234UNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Humphreys, ManjeetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, QinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peto, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
dos-Santos-Silva, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-482251
DOI: 10.1158/1055-9965.EPI-12-0526
Journal or Publication Title: Cancer Epidemiol. Biomarkers Prev.
Volume: 21
Number: 10
Page Range: S. 1783 - 1792
Date: 2012
Publisher: AMER ASSOC CANCER RESEARCH
Place of Publication: PHILADELPHIA
ISSN: 1538-7755
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; CONFER SUSCEPTIBILITY; COMMON VARIANTS; GENETIC RISK; IDENTIFIES 2; ALLELES; LINKAGE; 5P12; AGEMultiple languages
Oncology; Public, Environmental & Occupational HealthMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48225

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