Universität zu Köln

Lennertz, Leonhard, Rampacher, Friederike, Vogeley, Andrea, Schulze-Rauschenbach, Svenja, Pukrop, Ralf, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Klosterkoetter, Joachim, Maier, Wolfgang, Falkai, Peter ORCID: 0000-0003-2873-8667 and Wagner, Michael ORCID: 0000-0003-2589-6440 (2012). Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype. Eur. Arch. Psych. Clin. Neurosci., 262 (7). S. 625 - 635. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Cognitive dysfunctions such as inhibitory deficits and visuospatial abnormalities are often found in patients with obsessive-compulsive disorder (OCD). Recent findings in unaffected relatives indicate that response inhibition and other neuropsychological functions may also constitute endophenotypes of OCD. In the present study, 30 OCD patients, 30 first-degree relatives, and 30 healthy control subjects were assessed using a comprehensive neuropsychological test battery. A subsample of 21 subjects of each group also performed an antisaccade task. The samples were matched according to age, gender, education, and verbal intelligence. The OCD patients and the unaffected OCD relatives showed increased antisaccade error rates compared with the healthy control group (p = 0.003, p = 0.028, respectively). Significantly prolonged antisaccade latencies as compared to prosaccade latencies were only found in the OCD patients compared with the healthy control group (p = 0.019). Only OCD patients but not the unaffected OCD relatives were impaired with regard to visuospatial functions, problem-solving, and processing speed. Antisaccade errors did not correlate with severity of OCD or depressive symptoms. This study confirms inhibitory deficits, as indicated by increased antisaccade error rates, as a candidate endophenotype of OCD. In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lennertz, Leonhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Rampacher, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogeley, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulze-Rauschenbach, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Pukrop, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Falkai, Peter UNSPECIFIED orcid.org/0000-0003-2873-8667 UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-482331
DOI:	10.1007/s00406-012-0311-1
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	262
Number:	7
Page Range:	S. 625 - 635
Date:	2012
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROCOGNITIVE ENDOPHENOTYPES; EXECUTIVE DYSFUNCTIONS; COGNITIVE FLEXIBILITY; 1ST-DEGREE RELATIVES; MOTOR INHIBITION; EYE-MOVEMENTS; DEFICITS; SCHIZOPHRENIA; ABNORMALITIES; SACCADES Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48233