Universität zu Köln

Pedrosa, David J., Reck, Christiane, Florin, Esther ORCID: 0000-0001-8276-2508, Pauls, K. Amande M., Maarouf, Mohammad, Wojtecki, Lars, Dafsari, Haidar Salimi, Sturm, Volker, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Timmermann, Lars (2012). Essential tremor and tremor in Parkinson's disease are associated with distinct 'tremor clusters' in the ventral thalamus. Exp. Neurol., 237 (2). S. 435 - 444. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2430

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Abstract

Different tremor entities such as Essential Tremor (ET) or tremor in Parkinson's disease (PD) can be ameliorated by the implantation of electrodes in the ventral thalamus for Deep Brain Stimulation (DBS). The exact neural mechanisms underlying this treatment, as well as the specific pathophysiology of the tremor in both diseases to date remain elusive. Since tremor-related local field potentials (LFP) have been shown to cluster with a somatotopic representation in the subthalamic nucleus, we here investigated the neurophysiological correlates of tremor in the ventral thalamus in ET and PD using power and coherence analysis. Local field potentials (LFPs) at different recording depths and surface electromyographic signals (EMGs) from the extensor and flexor muscles of the contralateral forearm were recorded simultaneously in twelve ET and five PD patients. Data analysis revealed individual electrophysiological patterns of LFP-EMG coherence at single and double tremor frequency for each patient. Patterns observed varied in their spatial distribution within the Ventral lateral posterior nucleus of the thalamus (VLp), revealing a specific topography of 'tremor clusters' for PD and ET. The data strongly suggest that within VLp individual tremor-related electrophysiological signatures exist in ET and PD tremor. (C) 2012 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pedrosa, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reck, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Florin, Esther UNSPECIFIED orcid.org/0000-0001-8276-2508 UNSPECIFIED Pauls, K. Amande M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Wojtecki, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar Salimi UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnitzler, Alfons UNSPECIFIED orcid.org/0000-0002-6414-7939 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-482397
DOI:	10.1016/j.expneurol.2012.07.002
Journal or Publication Title:	Exp. Neurol.
Volume:	237
Number:	2
Page Range:	S. 435 - 444
Date:	2012
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2430
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; SINGLE-UNIT ANALYSIS; NUCLEAR GROUP; SUBTHALAMIC NUCLEUS; NEURONAL-ACTIVITY; MOTOR THALAMUS; INTERMEDIATE; COHERENCE; MOVEMENT; EEG Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48239