Universität zu Köln

Garcia-Marquez, Maria A., Wennhold, Kerstin ORCID: 0000-0001-5539-7226, Draube, Andreas and von Bergwelt-Baildon, Michael (2012). Results of a Phase II clinical trial with Id-protein-loaded dendritic cell vaccine in multiple myeloma: encouraging or discouraging? Immunotherapy, 4 (10). S. 991 - 995. LONDON: FUTURE MEDICINE LTD. ISSN 1750-743X

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Abstract

Evaluation of: Zahradova L, Mollova K, Ocadlikova D et al. Efficacy and safety of Id-protein-loaded dendritic cell vaccine in patients with multiple myeloma - Phase II study results. Neoplasma 59(4), 440-449 (2012). Recently gained insight into the role of dendritic cells (DCs) as APCs has attracted the attention of many researchers who hope to use them as a tool in immunotherapy for the induction of tumor-specific immunity in cancer settings. Despite high expectations, in multiple myeloma patients the results of DC-based vaccines in terms of clinical response have been disappointing. The findings of Zahradova et al. in a Phase II clinical trial with multiple myeloma patients corroborated these results. Although no clinical responses were observed, the investigators induced immunity after vaccination with Id-protein-loaded DC vaccine in some patients. These immunological results showed a trend towards a longer duration of stable disease in those patients that received the vaccination. Moreover, this study showed that Id-protein-loaded DC vaccines are safe and nontoxic and that they are able to induce immunity in some patients. Therefore, standardization of vaccination protocols appears to be the key to achieving a better clinical outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Garcia-Marquez, Maria A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wennhold, Kerstin UNSPECIFIED orcid.org/0000-0001-5539-7226 UNSPECIFIED Draube, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-482431
DOI:	10.2217/IMT.12.94
Journal or Publication Title:	Immunotherapy
Volume:	4
Number:	10
Page Range:	S. 991 - 995
Date:	2012
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1750-743X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMMUNE-RESPONSES; IDIOTYPE; TRANSPLANTATION; MIGRATION; INDUCTION; SURVIVAL; CD38 Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48243