Universität zu Köln

Rabenhorst, Anja, Schlaak, Max, Heukamp, Lukas C., Foerster, Anja, Theurich, Sebastian ORCID: 0000-0001-5706-8258, von Bergwelt-Baildon, Michael, Buettner, Reinhard, Kurschat, Peter, Mauch, Cornelia, Roers, Axel and Hartmann, Karin ORCID: 0000-0002-4595-8226 (2012). Mast cells play a protumorigenic role in primary cutaneous lymphoma. Blood, 120 (10). S. 2042 - 2055. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

Primary cutaneous lymphomas (PCLs) are clonal T-or B-cell neoplasms, which originate in the skin. In recent years, mast cells were described as regulators of the tumor microenvironment in different human malignancies. Here, we investigated the role of mast cells in the tumor microenvironment of PCL. We found significantly increased numbers of mast cells in skin biopsies from patients with cutaneous T-cell lymphoma (CTCL) and cutaneous B-cell lymphoma (CBCL). Mast cell infiltration was particularly prominent in the periphery, at lymphoma rims. Interestingly, CTCL and CBCL patients with a progressive course showed higher mast cell counts than stable patients, and mast cell numbers in different stages of CTCL correlated positively with disease progression. In addition, mast cell numbers positively correlated with microvessel density. Incubating primary CTCL cells with mast cell supernatant, we observed enhanced proliferation and production of cytokines. In line with our in vitro experiments, in a mouse model of cutaneous lymphoma, tumor growth in mast cell-deficient transgenic mice was significantly decreased. Taken together, these experiments show that mast cells play a protumorigenic role in CTCL and CBCL. Our data provide a rationale for exploiting tumor-associated mast cells as a prognostic marker and therapeutic target in PCL. (Blood. 2012; 120(10):2042-2054)

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rabenhorst, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaak, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Heukamp, Lukas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurschat, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauch, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Roers, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Karin UNSPECIFIED orcid.org/0000-0002-4595-8226 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-483198
DOI:	10.1182/blood-2012-03-415638
Journal or Publication Title:	Blood
Volume:	120
Number:	10
Page Range:	S. 2042 - 2055
Date:	2012
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYCOSIS-FUNGOIDES; GROWTH-FACTOR; SEZARY-SYNDROME; POOR-PROGNOSIS; EUROPEAN-ORGANIZATION; INTERNATIONAL-SOCIETY; TASK-FORCE; ANGIOGENESIS; CANCER; EXPRESSION Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48319