Universität zu Köln

Stevens, K. N., Garcia-Closas, M., Fredericksen, Z., Kosel, M., Pankratz, V. S., Hopper, J. L., Dite, G. S., Apicella, C., Southey, M. C., Schmidt, M. K., Broeks, A., Van 't Veer, L. J., Tollenaar, R. A. E. M., Fasching, P. A., Beckmann, M. W., Hein, A., Ekici, A. B., Johnson, N., Peto, J., Silva, I. dos Santos, Gibson, L., Sawyer, E., Tomlinson, I., Kerin, M. J., Chanock, S., Lissowska, J., Hunter, D. J., Hoover, R. N., Thomas, G. D., Milne, R. L., Perez, J. I. Arias, Gonzalez-Neira, A., Benitez, J., Burwinkel, B., Meindl, A., Schmutzler, R. K., Bartrar, C. R., Hamann, U., Ko, Y. D., Bruening, T., Chang-Claude, J., Hein, R., Wang-Gohrke, S., Doerk, T., Schuermann, P., Bremer, M., Hillemanns, P., Bogdanova, N., Zalutsky, J. V., Rogov, Y. I., Antonenkova, N., Lindblom, A., Margolin, S., Mannermaa, A., Kataja, V., Kosma, V-M, Hartikainen, J., Chenevix-Trench, G., Chen, X., Peterlongo, P., Bonanni, B., Bernard, L., Manoukian, S., Wang, X., Cerhan, J., Vachon, C. M., Olson, J., Giles, G. G., Baglietto, L., McLean, C. A., Severi, G., John, E. M., Miron, A., Winqvist, R., Pylkaes, K., Jukkola-Vuorinen, A., Grip, M., Andrulis, I., Knight, J. A., Glendon, G., Mulligan, A. M., Cox, A., Brock, I. W., Elliott, G., Cross, S. S., Pharoah, P. P., Dunning, A. M., Pooley, K. A., Humphreys, M. K., Wang, J., Kang, D., Yoo, K-Y, Noh, D-Y, Sangrajrang, S., Gabrieau, V., Brennan, P., Mckay, J., Anton-Culver, H., Ziogas, A., Couch, F. J. and Easton, D. F. (2011). Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk. Br. J. Cancer, 105 (12). S. 1934 - 1940. LONDON: NATURE PUBLISHING GROUP. ISSN 0007-0920

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Abstract

BACKGROUND: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of this study was to evaluate the association between inherited variation in this oncogene and risk of breast cancer. METHODS: A single-nucleotide polymorphism from the PIK3CA locus that was associated with breast cancer in a study of Caucasian breast cancer cases and controls from the Mayo Clinic (MCBCS) was genotyped in 5436 cases and 5280 controls from the Cancer Genetic Markers of Susceptibility (CGEMS) study and in 30 949 cases and 29 788 controls from the Breast Cancer Association Consortium (BCAC). RESULTS: Rs1607237 was significantly associated with a decreased risk of breast cancer in MCBCS, CGEMS and all studies of white Europeans combined (odds ratio (OR) = 0.97, 95% confidence interval (CI) 0.95-0.99, P = 4.6 x 10(-3)), but did not reach significance in the BCAC replication study alone (OR = 0.98, 95% CI 0.96-1.01, P = 0.139). CONCLUSION: Common germline variation in PIK3CA does not have a strong influence on the risk of breast cancer British Journal of Cancer (2011) 105, 1934 - 1939. doi: 10.1038/bjc.2011.448 www.bjcancer.com Published online 27 October 2011 (C) 2011 Cancer Research UK

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stevens, K. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Closas, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fredericksen, Z. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kosel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pankratz, V. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hopper, J. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dite, G. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Apicella, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Southey, M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, M. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broeks, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Van 't Veer, L. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tollenaar, R. A. E. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fasching, P. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beckmann, M. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hein, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ekici, A. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Johnson, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peto, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Silva, I. dos Santos UNSPECIFIED UNSPECIFIED UNSPECIFIED Gibson, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sawyer, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tomlinson, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kerin, M. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chanock, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lissowska, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hunter, D. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoover, R. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, G. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Milne, R. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Perez, J. I. Arias UNSPECIFIED UNSPECIFIED UNSPECIFIED Gonzalez-Neira, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Benitez, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burwinkel, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meindl, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, R. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartrar, C. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamann, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ko, Y. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chang-Claude, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hein, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang-Gohrke, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerk, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuermann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bremer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillemanns, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogdanova, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zalutsky, J. V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rogov, Y. I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonenkova, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lindblom, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Margolin, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mannermaa, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kataja, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kosma, V-M UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartikainen, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chenevix-Trench, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, X. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peterlongo, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonanni, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bernard, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Manoukian, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, X. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cerhan, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vachon, C. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Olson, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Giles, G. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baglietto, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED McLean, C. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Severi, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED John, E. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Miron, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Winqvist, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pylkaes, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jukkola-Vuorinen, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grip, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Andrulis, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knight, J. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Glendon, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mulligan, A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cox, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brock, I. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elliott, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cross, S. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pharoah, P. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunning, A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pooley, K. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Humphreys, M. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kang, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yoo, K-Y UNSPECIFIED UNSPECIFIED UNSPECIFIED Noh, D-Y UNSPECIFIED UNSPECIFIED UNSPECIFIED Sangrajrang, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gabrieau, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brennan, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mckay, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Anton-Culver, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziogas, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Couch, F. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Easton, D. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-483610
DOI:	10.1038/bjc.2011.448
Journal or Publication Title:	Br. J. Cancer
Volume:	105
Number:	12
Page Range:	S. 1934 - 1940
Date:	2011
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	0007-0920
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PIK3CA MUTATIONS; POOR-PROGNOSIS; HIGH-FREQUENCY; PTEN LOSS; GENE; ASSOCIATION; CORRELATE; PATHWAY; OVARIAN Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48361