Universität zu Köln

Visca, Paolo ORCID: 0000-0002-6128-7039, Seifert, Harald and Towner, Kevin J. (2011). Acinetobacter Infection - an Emerging Threat to Human Health. IUBMB Life, 63 (12). S. 1048 - 1055. MALDEN: WILEY-BLACKWELL. ISSN 1521-6543

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Abstract

The genus Acinetobacter comprises a complex and heterogeneous group of bacteria, many of which are capable of causing a range of opportunistic, often catheter-related, infections in humans. However, Acinetobacter baumannii, as well as its close relatives belonging to genomic species 3 (Acinetobacter pittii) and 13TU (Acinetobacter nosocomialis), are important nosocomial pathogens, often associated with epidemic outbreaks of infection, that are only rarely found outside of a clinical setting. These organisms are frequently pandrug-resistant and are capable of causing substantial morbidity and mortality in patients with severe underlying disease, both in the hospital and in the community. Several epidemic clonal lineages of A. baumannii have disseminated worldwide and seem to have a selective advantage over non-epidemic strains. The reasons for the success of these epidemic lineages remain to be elucidated, but could be related to the potential of these organisms to achieve very dynamic reorganization and rapid evolution of their genome, including the acquisition and expression of additional antibiotic resistance determinants, under fluctuating environmental and selective conditions. (C) 2011 IUBMB IUBMB Life, 63(12): 1048-1054, 2011

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Visca, Paolo UNSPECIFIED orcid.org/0000-0002-6128-7039 UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Towner, Kevin J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484285
DOI:	10.1002/iub.534
Journal or Publication Title:	IUBMB Life
Volume:	63
Number:	12
Page Range:	S. 1048 - 1055
Date:	2011
Publisher:	WILEY-BLACKWELL
Place of Publication:	MALDEN
ISSN:	1521-6543
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENOMIC SPECIES 13TU; MOLECULAR EPIDEMIOLOGY; NOSOCOMIAL BACTEREMIA; BAUMANNII; IDENTIFICATION; HOSPITALS; COMPLEX; DISSEMINATION; DIFFERENTIATE; CALCOACETICUS Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48428