Universität zu Köln

Deckert, M., Engert, A., Brueck, W., Ferreri, A. J. M., Finke, J., Illerhaus, G., Klapper, W., Korfel, A., Kueppers, R., Maarouf, M., Montesinos-Rongen, M., Paulus, W., Schlegel, U., Lassmann, H., Wiestler, O. D., Siebert, R. and DeAngelis, L. M. (2011). Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma. Leukemia, 25 (12). S. 1797 - 1808. LONDON: NATURE PUBLISHING GROUP. ISSN 0887-6924

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Abstract

Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL. Leukemia (2011) 25, 1797-1807; doi:10.1038/leu.2011.169; published online 5 August 2011

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Deckert, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueck, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferreri, A. J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Finke, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Illerhaus, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klapper, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Korfel, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kueppers, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Montesinos-Rongen, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paulus, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlegel, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lassmann, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiestler, O. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebert, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED DeAngelis, L. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484924
DOI:	10.1038/leu.2011.169
Journal or Publication Title:	Leukemia
Volume:	25
Number:	12
Page Range:	S. 1797 - 1808
Date:	2011
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	0887-6924
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY-CNS-LYMPHOMA; NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMAS; HIGH-DOSE CHEMOTHERAPY; WHOLE-BRAIN RADIOTHERAPY; IMMUNE-PRIVILEGED SITES; MULTICENTER PHASE-II; INTRAOCULAR LYMPHOMA; GENE-EXPRESSION; INFLAMMATORY DEMYELINATION Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48492