Universität zu Köln

Mareck, Ute, Guddat, Sven, Schwenke, Anne, Beuck, Simon, Geyer, Hans, Flenker, Ulrich, Elers, Jimmi, Backer, Vibeke ORCID: 0000-0002-7806-7219, Thevis, Mario and Schaenzer, Wilhelm (2011). Determination of salbutamol and salbutamol glucuronide in human urine by means of liquid chromatography-tandem mass spectrometry. Drug Test. Anal., 3 (11-12). S. 820 - 828. HOBOKEN: WILEY-BLACKWELL. ISSN 1942-7611

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Abstract

The determination of salbutamol and its glucuronide in human urine following the inhalative and oral administration of therapeutic doses of salbutamol preparations was performed by means of direct urine injection utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS) and employing d3-salbutamol and d3-salbutamol glucuronide as internal standards. Unconjugated salbutamol was detected in all administration study urine samples. Salbutamol concentrations following inhalation were commonly (99%) below 1000?ng/ml whereas values after oral administration frequently (48%) exceeded this threshold.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mareck, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Guddat, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwenke, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Beuck, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Flenker, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Elers, Jimmi UNSPECIFIED UNSPECIFIED UNSPECIFIED Backer, Vibeke UNSPECIFIED orcid.org/0000-0002-7806-7219 UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-485723
DOI:	10.1002/dta.367
Journal or Publication Title:	Drug Test. Anal.
Volume:	3
Number:	11-12
Page Range:	S. 820 - 828
Date:	2011
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOPING CONTROL Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48572