Universität zu Köln

Pyrc, Krzysztof ORCID: 0000-0002-3867-7688, Strzyz, Paulina ORCID: 0000-0001-6086-1361, Milewska, Aleksandra, Golda, Anna, Schildgen, Oliver ORCID: 0000-0003-4297-9627 and Potempa, Jan (2011). Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro. J. Gen. Virol., 92. S. 2324 - 2333. READING: SOC GENERAL MICROBIOLOGY. ISSN 0022-1317

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Abstract

Relatively recently discovered, human metapneumovirus (HMPV) is a human pathogen with worldwide prevalence, accounting for a substantial percentage of respiratory tract diseases. Concurrent viral and bacterial infections enable intricate mechanisms of cooperation between pathogens, which complicate the symptoms and outcome of the disease. Such bilateral interactions are based on the modulation of bacterial growth on epithelium pathologically altered during viral illness and the modulation of immune responses, as well as the enhancement of virus replication by bacterial virulence factors. This study showed that proteases produced by Porphyromonas gingivalis, a Gram-negative bacterium implicated in the development of periodontitis, named gingipains, facilitated HMPV replication in LLC-MK2 cells and may contribute to HMPV pathogenicity in patients with periodontitis. Gingipains at low nanomolar concentrations enabled HMPV replication and allowed virus propagation in vitro. In contrast to previously published data for influenza virus, however, Staphylococcus aureus proteases and human neutrophil elastase did not affect virus replication.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pyrc, Krzysztof UNSPECIFIED orcid.org/0000-0002-3867-7688 UNSPECIFIED Strzyz, Paulina UNSPECIFIED orcid.org/0000-0001-6086-1361 UNSPECIFIED Milewska, Aleksandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Golda, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED Potempa, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-487850
DOI:	10.1099/vir.0.032094-0
Journal or Publication Title:	J. Gen. Virol.
Volume:	92
Page Range:	S. 2324 - 2333
Date:	2011
Publisher:	SOC GENERAL MICROBIOLOGY
Place of Publication:	READING
ISSN:	0022-1317
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RESPIRATORY-TRACT DISEASE; PERIODONTAL HEALTH-STATUS; ASPIRATION PNEUMONIA; CYSTEINE PROTEINASES; FUSION PROTEIN; STAPHYLOCOCCUS-AUREUS; TREPONEMA-DENTICOLA; INFLUENZA PNEUMONIA; RSV BRONCHIOLITIS; GENETIC DIVERSITY Multiple languages Biotechnology & Applied Microbiology; Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48785