Hermann, Manuel Marcel, Bron, Alain Marie, Creuzot-Garcher, Catherine P. and Diestelhorst, Michael (2011). Measurement of Adherence to Brimonidine Therapy for Glaucoma Using Electronic Monitoring. J. Glaucoma, 20 (8). S. 502 - 509. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-481X
Full text not available from this repository.Abstract
Purpose: To assess the patient adherence and behavior with brimonidine twice daily (bid) or 3 times daily (tid) in patients used to topical glaucoma medication. Patients and Methods: Seventy-five patients with glaucoma or ocular hypertension were enrolled in a prospective, observational cohort study. Consenting patients were randomly assigned to brimonidine bid or tid and received conventional brimonidine eye drops with attached electronic monitoring devices for 4 weeks. Patients were not explicitly informed on the compliance monitoring. Results: The study was completed by 67 patients (89%). In 65 patients (97%), at least 1 dosing interval exceeded 24 hours. The mean adherence rates were better in the brimonidine bid group (72 + 19% vs. 62 + 16%, P = 0.04), although dosing frequency was higher in the tid group (1.9 perpendicular to 0.5 vs. 1.4 perpendicular to 0.4 per day; P < 0.001). On average medication coverage was 70% for the bid group and 67% for the tid group; 19 patients (28%) had a coverage rate above 75%, 42 patients (63%) 50% to 75%, and 6 (9%) below 50%. Patients with normal-tension glaucoma had lower coverage rates than patients with primary open-angle glaucoma and ocular hypertension (P < 0.05). Data also showed that on average 20% of the glaucoma medication was wasted owing to inefficient drug delivery by using more than 1 drop per dosing. Conclusions: Individual adherence with brimonidine was highly variable and pharmacologically insufficient for more than two-third of the patients. Special attention should be paid to compliance of patients with normal-tension glaucoma. Our findings underline the need to improve individual adherence and drug delivery in topical glaucoma therapy.
Item Type: | Journal Article | ||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-488038 | ||||||||||||||||||||
DOI: | 10.1097/IJG.0b013e3181f3eb4a | ||||||||||||||||||||
Journal or Publication Title: | J. Glaucoma | ||||||||||||||||||||
Volume: | 20 | ||||||||||||||||||||
Number: | 8 | ||||||||||||||||||||
Page Range: | S. 502 - 509 | ||||||||||||||||||||
Date: | 2011 | ||||||||||||||||||||
Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||||||||||||||||||
Place of Publication: | PHILADELPHIA | ||||||||||||||||||||
ISSN: | 1536-481X | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/48803 |
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