Lindenberg, Annette, Brinkmeyer, Juergen, Dahmen, Norbert, Gallinat, Juergen, de Millas, Walter, Mobascher, Arian, Wagner, Michael ORCID: 0000-0003-2589-6440, Schulze-Rauschenbach, Svenja, Gruender, Gerhard, Spreckelmeyer, Katja N., Clepce, Marion, Thuerauf, Norbert, von der Goltz, Christoph, Kiefer, Falk, Steffens, Michael ORCID: 0000-0002-6445-8593, Holler, Daniela, Diaz-Lacava, Amalia, Wienker, Thomas and Winterer, Georg (2011). The German multi-centre study on smoking-related behavior-description of a population-based case-control study. Addict. Biol., 16 (4). S. 638 - 654. HOBOKEN: WILEY. ISSN 1369-1600

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Abstract

Tobacco smoking is a major risk factor for most of the diseases leading in mortality. Nicotine dependence (ND), which sustains regular smoking, is now acknowledged to be under substantial genetic control with some environmental contribution. At present, however, genetic studies on ND are mostly conducted in populations that have been poorly characterized with regard to ND-related phenotypes for the simple reason that the respective populations were not primarily collected to study ND. The Germanmulti-centre study 'Genetics of Nicotine Dependence and Neurobiological Phenotypes', which is funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) as part of the Priority Program (Schwerpunktprogramm) SPP1226: 'Nicotine-Molecular and Physiological Effects in CNS', was intended to overcome some of these inherent problems of current genetic studies of ND. The multi-centre study is a population-based case-control study of smokers and never-smokers (n = 2396). The study was unique worldwide because it was the first large-scale genetic study specifically addressing ND with the collection of a wide range of environmental, psychosocial and neurobiological phenotypes. Study design and major population characteristics with emphasis on risk prediction of smoking status were presented in this paper.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lindenberg, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brinkmeyer, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahmen, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallinat, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Millas, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mobascher, ArianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Schulze-Rauschenbach, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruender, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spreckelmeyer, Katja N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clepce, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thuerauf, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von der Goltz, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiefer, FalkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steffens, MichaelUNSPECIFIEDorcid.org/0000-0002-6445-8593UNSPECIFIED
Holler, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diaz-Lacava, AmaliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wienker, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winterer, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-488193
DOI: 10.1111/j.1369-1600.2011.00322.x
Journal or Publication Title: Addict. Biol.
Volume: 16
Number: 4
Page Range: S. 638 - 654
Date: 2011
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1369-1600
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MULTIVARIATE GENETIC-ANALYSIS; COLORADO-ADOPTION-PROJECT; NICOTINE DEPENDENCE; COGNITIVE-ABILITY; EDUCATIONAL-ATTAINMENT; ACADEMIC-ACHIEVEMENT; IMPULSIVITY PREDICTS; ADOLESCENT; TOBACCO; INITIATIONMultiple languages
Biochemistry & Molecular Biology; Substance AbuseMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48819

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