Universität zu Köln

Scheel, Christian, Rotarska-Jagiela, Anna, Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Lehnhardt, Fritz G., Krug, Barbara, Vogeley, Kai and Tepest, Ralf ORCID: 0000-0002-2421-2652 (2011). Imaging derived cortical thickness reduction in high-functioning autism: Key regions and temporal slope. Neuroimage, 58 (2). S. 391 - 401. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Cortical thickness (CT) changes possibly contribute to the complex symptomatology of autism. The aberrant developmental trajectories underlying such differences in certain brain regions and their continuation in adulthood are a matter of intense debate. We studied 28 adults with high-functioning autism (HFA) and 28 control subjects matched for age, gender. IQ and handedness. A surface-based whole brain analysis utilizing FreeSurfer was employed to detect CT differences between the two diagnostic groups and to investigate the time course of age-related changes. Direct comparison with control subjects revealed thinner cortex in HFA in. the posterior superior temporal sulcus (pSTS) of the left hemisphere. Considering the time course of CT development we found clusters around the pSTS and cuneus in the left and the paracentral lobule in the right hemisphere to be thinner in HFA with comparable age-related slopes in patients and controls. Conversely, we found clusters around the supramarginal gyrus and inferior parietal lobule (IPL) in the left and the precentral and postcentral gyrus in the right hemisphere to be thinner in HFA, but with different age-related slopes in patients and controls. In the latter regions CT showed a steady decrease in controls but no analogous thinning in HFA. CT analyses contribute in characterizing neuroanatomical correlates of HFA. Reduced CT is present in brain regions involved in social cognition. Furthermore, our results demonstrate that aberrant brain development leading to such differences is proceeding throughout adulthood. Discrepancies in prior morphometric studies may be induced by the complex time course of cortical changes. (C) 2011 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scheel, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rotarska-Jagiela, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Lehnhardt, Fritz G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogeley, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Tepest, Ralf UNSPECIFIED orcid.org/0000-0002-2421-2652 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489016
DOI:	10.1016/j.neuroimage.2011.06.040
Journal or Publication Title:	Neuroimage
Volume:	58
Number:	2
Page Range:	S. 391 - 401
Date:	2011
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN CEREBRAL-CORTEX; MIRROR-NEURON SYSTEM; VOXEL-BASED MORPHOMETRY; EARLY BRAIN-DEVELOPMENT; SURFACE-BASED ANALYSIS; SOCIAL COGNITION; SPECTRUM DISORDERS; ASPERGER-SYNDROME; PERCEPTION; MRI Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48901